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Drugs and Depression
Pharmacology Exam 4
23
Pharmacology
Professional
04/11/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
Serotonin (5-HT2)
Definition
improved mood, modulation of anxiety, sleep regulation, appetite regulation, and regular body temp
Term
Norepinephrine (NE)
Definition
improved mood, fight or flight, mental organization, rewards, cardiovascular
Term
Dopamine (DO)
Definition
improved mood, psychosis, attention/cognition, reward/reinforcement of pleasure activities, motor function
Term
acetylcholine (ACH)-antagonism
Definition
urinary retention, dry mouth, constipation, tachycardia, learning, muscle action
Term
Histamine (H1)-antagonism
Definition
sedation, weight gain
Term
treat BOTH depression and anxiety
Definition
SSRIs, SNRIs, MAOIs and atypical antidepressants
Term
SSRIs (selective serotonin reuptake inhibitors)
Definition
fluoxetine, sertraline, fluvoxamine, citalopram, escitalopram, paroxetine
Term
adverse effects of SSRIs
Definition
anxiety, agitation, akathiesia, panic, insomnia, sexual dysfunction, hyponatremia, decreased in platelet aggregation; bleeding risk
Term
SNRI (selective norepinephrine reuptake inhibitors)
Definition
Amitriptyline, clomipramine, desimipramine, doxepin, duloxetine, imipramine, nortriptyline, venlafaxine/desvenlafacine
Term
Adverse effects to SNRIs
Definition
severe sedation, constipation, weight gain, cardiovascular, orthostatic hypotension, sexual dysfunction, insomnia, sweating and tremors
Term
MAOIs
Definition
phenelzine, tranylcyromine and selegiline
Term
adverse effects of MAOIs
Definition
orthostatic hypertension, drowsiness, constipation, tremors, hypertensive crisis, anxiety
Term
atypical antidepressants
Definition
nefazodone, trazodone, buproprion, mirtazapine, and vilazodone
Term
Serzone (nefazodone)
Definition
inhibits reuptake of serotonin and NE; 5-HT2 and alpha 1 receptor antagonist
Term
adverse effects of nefazodone
Definition
somnolence, dizziness, constipation, orthostatic hypoTN and liver failure (RARE)
Term
Desyrel (trazodone)
Definition
inhibits reuptake of serotonin, histamine, alpha 1 adrenergic receptor antagonist
Term
adverse effects of trazodone
Definition
blurred vision, dizziness, dry mouth, nasal congestion and priapism--used mainly for SE (drowsiness)
Term
Wellbutrin (bupropion)
Definition
blocks reuptake of NE and DO--uses include depression, smoking cessation and ADHD
Term
adverse effects of bupropion
Definition
HA, dry mouth, weight loss, insomnia and agitation/ anxiety
Term
Remeron (mirtazapine)
Definition
presynaptic alpha 2 antag that effects stimulates NE and serotonin release; potent antag of 5-HT2, 5-HT3 and histamine receptors
Term
adverse effects of mirtazapine
Definition
somnolence, weight gain, increased appetite, constipation, xerostomia
Term
Biibryd (vilazodone)
Definition
selective serotonin reuptake inhibitor and partial agonist 5-HT1A receptors (exact MOA is not entirely known)
Term
adverse effects of vilazodone
Definition
GI-diarrhea, nausea, neurological (dizziness and insomnia), cardiovascular (palpitations, ventricular premature beats)
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