Term
| What is the adrenergic effect of Alpha 1 receptors of the radial muscle of the eye? |
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Definition
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Term
| What is the adrenergic effect of Beta 2 receptors of the ciliary muscle of the eye? |
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Definition
| Relaxation for far vision. |
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Term
| What is the Alpha 1 receptor effect on salivary glands? |
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Definition
| Secretion of potassium and water |
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Term
| What is the Adrenergic effect of Beta 1 stimulation of the SA node of the heart? |
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Definition
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Term
| Drugs in which class are associated with rebound hypertensions associated with SNS activity after sudden withdrawal of the drugs? |
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Definition
| Alpha2 Adrenergic agonists. |
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Term
| Clonidine and methyldopa are more likely to cause rebound hypertension if stopped suddenly while given concurrently with which class of drugs? |
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Definition
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Term
| What is the oral duration of clonidine? |
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Definition
|
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Term
| What is the oral onset of clonidine? |
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Definition
|
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Term
| What is the onset of transdermal clonidine? |
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Definition
|
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Term
| What is the duration of transdermal clonidine? |
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Definition
| 7 days (8 hours of effect after patch is removed) |
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Term
| What is the half life of PO clonidine? |
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Definition
| 12-16 hours; up to 41 hours if impaired renal function |
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Term
| What is the time of onset of anti htn action for oral Guanabenz? |
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Definition
|
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Term
| When is the peak of Guanabenz? |
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Definition
|
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Term
| What is the duration of Guanabenz? |
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Definition
|
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Term
| What is the protein binding percentage of Guanabenz? |
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Definition
|
|
Term
| What is the half life of Guanabenz? |
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Definition
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Term
| What is the onset of Guanfacine PO? |
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Definition
|
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Term
| When does Guanfacine peak? |
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Definition
|
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Term
| What is the duration of Guanfacine? |
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Definition
|
|
Term
| What is the protein binding percentage of Guanfacine? |
|
Definition
|
|
Term
| What is the bioavailability of Guanfacine? |
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Definition
|
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Term
| What is the half-life of Guanfacine? |
|
Definition
| Adults: 17h; Young adults: 13-14h; older adults: 17-18h. |
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Term
| What is the onset of Methyldopa? |
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Definition
|
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Term
| When is the peak of methyldopa? |
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Definition
|
|
Term
| What is the duration of action of methyldopa? |
|
Definition
|
|
Term
| What is the protein binding percentage of methyldopa? |
|
Definition
|
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Term
| What is the bioavailability of methyldopa? |
|
Definition
|
|
Term
| What is the half life of Methyldopa? |
|
Definition
| 1-8h. Blood pressure reduction is pronounced and prolonged in renal failure. |
|
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Term
| What percentage of methyldopa is secreted in urine as metabolites?? Where is it extensively metabolized? |
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Definition
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Term
| Which drugs block antihypertensive effects of clonidine and may result in life-threatening HTN? |
|
Definition
| Tricyclic Antidepressants |
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Term
| If given with clonidine, this drug has possible Synergistic pharmacological and toxic effects; may result in atrioventricular block and severe hypotension |
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Definition
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Term
| If given with clonidine, this drug can lead to decreased antihypertensive effect of clonidine |
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Definition
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Term
| Avoid concurrent use of these drugs with clonidine; if patient is taking both drugs and withdrawal is required, withdraw ___________ first to prevent excessive unopposed ______ stimulation that may lead to malignant HTN within 12 h |
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Definition
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Term
| Avoid concurrent use of these drugs with clonidine to help prevent additive sedation: (5 drugs) |
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Definition
| Alcohol, antihistamines, phenothiazines, barbiturates, and benzodiazepines |
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Term
| An alternative drug should be used to this drug when prescribing methyldopa due to possible potentiation of antipsychotic effects or possible psychosis: |
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Definition
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Term
| Concurrent prescribing of this drug with methyldopa can increase the risk of toxicity related to the drug. |
|
Definition
| Lithium-choose alternative antiHTN. |
|
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Term
| Prescribing these drugs concurrently with methyldopa can lead to release of endogenous catecholamines and result in excessive SNS stimulation. |
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Definition
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Term
| Prescribing this drug with methyldopa can result in enhanced hypoglycemic effects. |
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Definition
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Term
| These herbal substances may affect electrolyte levels and may decrease efficacy of methyldopa |
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Definition
| Licorice, yohimbe, ginseng; monitor blood pressure and inform patient. |
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Term
| This drug has been associated with the development of a positive Coombs’ test. Rarely, this is associated with hemolytic anemia |
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Definition
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