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Drugs Affecting GI Secretions
Ch. 57. Must know for test 5 as well
71
Nursing
Undergraduate 1
10/06/2013

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Term
Cimetidine (Tagamet)
Definition
Histamine -2 Antagonist
Term
Famotidine
Definition
Pepcid
Histamine-2 (H2) Antagonist
Term
Ranitidine
Definition
Zantac
Histamine -H2) Antahonist
Term
Nizatidine
Definition
AXID
Histamine H2 Antagonist
Term
Hystamine -2 (H2) antagonist
*cimetidine( Tagament)
*famotidine( pepsid)
*ranitidine (Zantac)
*nazatidine(AXID)
Definition
Reduces gastric secretions, prevents histamine induced acid release cimetidine associated with gynecomastia and galactorhea short term Tx of duodenal ulcers prevention of upper GI-bleed in critically ill patients Avoid antacids 1-2 hours before taking drug
Term
Antacids:
Prototype :Sodium Bicarbonate (Bell/ans;Baking-Soda)
Aluminum-salts(AlternaGel)
Calcium salts (Oystercal;Tums;Rolaids)
Magaldrate(Losopan;Riopan)
Aluminum-hydroxide/magnesium-hydroxide/simethicone(Mylanta)
Magaldrate/simethicone(Riopan Plus)
Magnesium-trisilate/Alumimum-hydroxide (Gaviscon)
Aluminum-hydroxide/magnesium-hydroxide (Maslox)
Simethicone (Gas-X; Mylicon)
Definition
Magnesium= Diarrhea
Aluminum= constipation
Take antacids 1 hour after meals
No Oral Meds within 1-2 hours of any antacid
MOM = also used as a laxative
Term
Sodium-Bicarbonate
Definition
Bell/ans Baking Soda
ANTACIDS
Term
Aluminum Salts
Definition
AlternaGel
ANTACID
Term
Calcium Salts
Definition
Oystercal; Tums;Rolaids
ANTACID
Term
Magaldrate
Definition
Losopan; Riopan
ANTACIDS
Term
Magnesium Salts
Definition
MOM
ANTACIDS
Term
Aluminum-hydroxide/magnesium-hydroxide/simethicone
Definition
Mylanta
ANTACIDS
Term
Magaldrate/Simethicone
Definition
Riopan Plus
ANTACIDS
Term
Magnesium-Trisilicate/ Aluminum-Hydroxide
Definition
Gaviscon
ANTACID
Term
Aluminum-Hydroxide
Magnesium-hydroxide
Definition
Maalox
ANTACID
Term
Simethicone
Definition
Gas-X; Mylicon
ANTACID
Term
Proton-Pump-Inhibitors (PPIs)
(prazole ending)
Omeprezole(Prilosec)
Esomeprazole(Nexium)
Lansoprazole(Prevacid)
Pantoprazole(Protonix)
Rabeprazole(Aciphex)
Definition
*Reduces Gastric acid production
*Short term Tx of GERD; *Omeprazole-Long term TC of duodenal ulcer
*Prevacid -Protonix - also available IV route
* May increase concentration of Oral Anticoagulants w/Omeprazole
Take Omeprazole before meals
Term
Omeprazole
Definition
Prilosec
PROTON PUMP INHIBITORS
Term
Esomeprazole
Definition
Nexium
PPIs
Term
Lansoprazole
Definition
Prevacid
PPIs
Term
Pantoprazole
Definition
Protonix
PPIs
Term
Rabeprazole
Definition
Aciphex
PPIs
Term
GI protectant
Carafate
Sucralfate
Definition
Forms a protective covering on ulcer surface take on empty stomach give 30 minutes āc/PC meals 1-2 b/w other meals
Term
PROSTOGLANDIN
Cytotec
Misoprostol
Definition
An Abortifacent stimulates uterine contractions helps NSAID induced gastric Ulcers
Term
Digestive-Enzymes
Pacrelipase (Creon; Prancrease)
Saliva-Substitute (MouthKote;Salivart)
Definition
Treatment of digestive-enzyme did function; take with all meals & snacks
Term
Pacrelipase
Definition
Creon; Prancrease
DIGESTIVE ENZYMES
Term
Saliva-substitute
Definition
MouthKote;Salivart
DIGESTIVE ENZYMES
Term
Drugs Affecting GI Motility
LAXATIVES
Definition
Chemical Stimulants
*Bulk-stimulants
*Lubricants/Emollients
*Other Laxatives
Term
Castor-Oil
Definition
Neoloid
CHEMICAL STIMULANT
Increases peristalsis
Term
Bisacodyl
Definition
Dulcolax
CHEMICAL STIMULANT
Gastric irritation if taken with antacids, H2 Blockers, PPIs and Milk
Term
Cascara
Definition
Chemical Stimulant
Term
Senna
Definition
Senokot
CHEMICAL STIMULANT
Term
Magnesium-Citrate
Definition
Citrate Magnesium
BULK STIMULANT
For Chronic constipation
Term
Lactulose
Definition
Chronulac
BULK STIMULANT
IF NOT TAKEN WITH WATER MAU HAVE CRAMPS NAUSEA DIARRHEA INTESTINAL OBSTRUCTION
Term
Magnesium hydroxide
Definition
MILK OF MAGNESIA
BULK STIMULANT
Term
Magnesium Sulfate
Definition
Epsom-Salts
BULK STIMULANT
OLD TOME REMRDY USED FOR VARIOUS PURPOSES.
Term
Methycellulose
Definition
Citrucel
BULK STIMULANT
Term
Polycarbophil
Definition
FiberCon
Mix with 8-10 oz of water & stir drink immediately & follow with 1 extra glass of water must be taken with plenty if water
Term
Psyllium
Definition
Metamucil; Fiberall
BULK STIMULANT
Term
Polyethylene- glycol
Definition
GloLYTELY
BULK STIMULANT
STIMULATE BOWL EVACUATION PROOR TO COLONOSCOPY
Term
LuBricants/Emollients
Definition
Mineral-Oil (Agoral Plain)
Dicusate-Sodium (Colace)
Glycerin (Sani-Supp)
Term
Mineral-Oil (Agoral Plain)
Definition
Lubricants/Emollients
softens stools by increasing water &fat penetration in the intestines if taken with mineral oil may result in toxicity
Term
Docusate-Sodium (Colace)
Definition
Lubricants/ Emollient
Colace prevents straining with BMs for post op, post partum, post Mi.
Term
Glycerin(Sani Supp)
Definition
May take up to 3 days to soften Stools
Term
OTHER LAXATIVES
METHYLNALTREXONE (Relistor)
Definition
For opioid induced constipation in specific Pts administers subcut daily also listed under agents for IBS
Term
GI- Stimulants
Metoclopramide (Reglan)
Despanthenol (llopan)
Definition
Pro-kinetic, anti-emetic. Chronic use> tardive dyskinesia; also listed under non-phenothiazine
Term
Loperamide (Imodium; Immodium A-D)
Definition
ANTI-DIRRHEALS
Inhibits gastric motility
Term
Bismuth-subsalicylate (Pepto-Bismol; Kaopectate)
Definition
Contains ASPIRIN may be used for travelers diarrhea CAUTION with: hepatic/Renal disease; Glaucoma
Term
Diphrnoxylate- hydrochloride/atropine-sulfate (Lomotil)
Definition
ANTIDIARRHEALS
Do not use if or has C-Diff infection (Clostridium difficile) CDI* No alcohol, MAO inhibitors, antihistamines, narcotics & sedative-hypnotics "Disulfram-reaction"
Term
Opium-derivatives (Paregoric)
Definition
ANTI-DIARRHEALS
ASSESS FREQUENT BM &/or vowel sounds
Term
Fidaxomicin (Dificid; Dificlir)
Definition
2nd FDA approved (2013) drug for tx of CDI (1st was oral vancomycin in 1978)
Term
(Prototype) Alostron (Lotronex)
Definition
IBS
Term
Tegaserod (Zelnorm)
Definition
IBS
Term
Hyoscyamine (Anaspaz; Levsin;NuLev
Definition
IBS
Term
Lubiprostone (AMITIZA)
Definition
IBS
Term
PHENOTHIAZINES
Endings: "azine"
Definition
Prochlorperazine (Compazine)
Chlorpromazine (Phenergan)
Pro methazine (Phenergan)
Perphenazine (Trilafon)
Term
Prochlorperazine (Compazine)
Definition
PHENTHIAZINE
Tx of N/V related to anesthesia; severe-vomiting; intractable-hiccoughs
Term
Chlorpromazine (Thorazine)
Definition
Photosensitivity> prochlorpetazine/Compazine
Term
Promethazine (Phenergan)
Definition
PHENOTHIAZINE
Adverse effects: drowsiness dry mouth pallor sweating urine may be tinged pink-to-red-brown color **Photosemsitivity**
Men steal disorders galactorhea gynecomastia
Term
NON-PHENOTHIAZINE
Definition
Metoclopramide
Reglan; Metozolv ODT
(Pro kinetic anti emetic ) (chronic use > Tardivr -Dyskinesia) (emetiginc cancer chemo, post op n/v
ADVERSE EFFECTS: drowsiness; sedating fatigue restlessness
Term
Meclizine (Antivert)
Prototype
buclizine( Bucladin)
Cyclizine (Marezine)
Definition
ANTI- CHOLORGENIC/ ANTIHISTAMINES (Prevent or treat n/v related to motion sickness or inner ear problems to prevent motion sickness (30 minutes prior to travel Many OTCs ADVERSE EFFECTS: DROWSINESS CONFUSION RESPIRATORY DEPRESSION ANOREXIA DRY MOUTH HYPOTENSION
Term
Serotonin 5- HT3 Receptor Blockers (SETRON)
Prototype: (ondansetron - Zofran)
(Dolasetron - Anzemet)
( granisetron- Kytril)
(Palonosetron- Aloxi)
Definition
For N/V related to anti-neoplasmic chemo radiation therapy post op CAUTION: pregnancy & lactation
ADVERSE EFFECTS: HA, DIZZINESS, Pain at injection site rash urinary retention constipation hypotension
Term
Substance P/Neurokinin 1 Receptor
Prototype : Aprepitant (Emend)
Definition
First drug in newest drug class for N/V in combination with other agents given Orally ADVERSE SIDE EFFECTS : Nausea HA constipation DO NOT GIVE DURING PREGNANCY DO NOT COMBINE W/ PIMOZIDE
Term
Drionabil (Marinol)
MISCELLANEOUS AGENTS
(Anti-Em)
Definition
Contains active ingredient of cannabis (Marijuana)
Term
Nabilone (Cesamet)
MISC-Agent (Anti Em)
Definition
Contains active ingredient of cannabis
Term
Hydroxine (Vistaril)
Definition
For N/V before or after obstetrical delivery or surgery
Term
Trimethobenzamide (Tigan)
Misc-Ag (AntiEm)
Definition
Similar to antihistamines but not as sedating
Term
Dexamethasone (Decadron)
MISC-Ag (AntiEM)
Definition
Corticosteroid (Pre -Chemo)
Term
Dimenhydrate (Dramamime)
Misc-Ag (AntiEM)
Definition
Antihistamine antiussive
Term
Scopolamine (Transderm-Scop)
Misc-AG (Anti-Em)
Definition
To prevent motion sickness take 30 minutes prior to travel DO NOT GIVE: COMA SEVERE CNS DEPRESSION, BRAIN-DAMAGE/Injury hypo/Hypertension liver dysfunction **No-Alcohol**
Term
Herbals/ Alternatives
Ginger
Definition
For Nausea
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