Term
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Definition
- Antiplatelets
- COX1 and COX2 inhibitor
- reduce platelet aggregation
- T1/2= 15 min to 12 hrs
- onset 5-30 min, duration 3-6 hrs
- analgetic and antiinflammatory
- reduces the risk of recurrent TIA, CVA, MI
- ADR: GI erosion, decreased renal blood flow, bleeding, bronchoconstriction (5-10%), Reye's syndrome in peds
- metabolized in the liver, excreted in urine
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Term
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Definition
- Antiplatelets
- ADP receptor inhibitor
- prodrug, active form in the liver
- may be inhibited by omeprazole
- stomach distress
- thrombocytopenic purpura (TTP) within the first 2 weeks of tx
- aplastic anemia, bleeding
- 75 mg daily, starting dose 300 mg x1
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Term
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Definition
- Antiplatelets
- PDE (phosphodiesterase) inhibitors - increase cAMP
- metabolized in liver, excreted in bile
- t1/2=10 hrs
- used in combination with warfarin for thromboembolism prophylaxis
- ADP: GI disturbance syncope, hypotension, rash
- 75-100 mg QID or 150-400mg/d with ASA
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Term
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Definition
- Antiplatelets
- PDE inhibitors
- used only for peripheral arterial disease, intermittent claudication
- vasodilation, increase HDL and decrease triglycerides
- 12 for full effects to develop
- reverse 48 hrs after withdrawal
- metabolized in liver
- inhibited by omeprazole
- Contraindicated - HF, active bleeding, hemostatic disorders
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Term
| Eptifibatide (Integrelin) |
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Definition
- Antiplatelets
- Glycoprotein IIb/IIIa (fibrinogen receptor) inhibitors
- "super aspirins"
- Acute coronary syndrome, unstable angina, PTCA, coronary stenting
- expensive
- cyclic peptide
- platelet aggregation restored within 6-12 hours
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Term
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Definition
- Antiplatelets
- Thrombin receptor antagonist (reversible)
- block thrombin-induced platelet activation
- long t1/2= few days - thus the final effect is irreversible
- approved May 2014 - expensive
- USED pts h/o MI and PAD
- NOT RECOMMENDED pts h/o stroke, TIA, intracranial hemorrhage
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