Term
| Clinical uses of Na+ channel blockers |
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Definition
local anesthetics
anti-arrhythmic
anti-epileptics |
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Term
| Suffix for local anesthetics |
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Definition
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Term
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Definition
ester local anesthetic
Example: procaine |
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Term
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Definition
amide local anesthetic
exampe: lidocaine |
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Term
Ester or amide local anesthetic?
cocaine
lidocaine
procaine
prilocaine |
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Definition
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Term
Cocaine: unique feature
mode of action |
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Definition
the only local anesthetic that is a vasoconstrictor;
it stimulates the CNS by causing the release and blocking the reuptake of neurotransmitters (epinephrine, NE, and dopamine) |
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Term
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Definition
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Term
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Definition
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Term
Ester local anesthetic characteristics:
half-life
metabolism
allergic reactions
toxicity |
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Definition
half-life: short
metabolism: rapid/plasma
allergic reactions: possible
toxcity: low |
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Term
amide local anesthetic characteristics:
half-life
metabolism
allergic reactions
toxicity |
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Definition
half-life: long
metabolism: complex/hepatic
allergic reactions: rare/non-existant
toxicity: higher; dose dependent |
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Term
What happens in each phase?
[image] |
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Definition
0--Na+ in
1--K+ out
2--Ca2+ in; K+ out
3--K+ out
4--Ca2+ in |
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