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Drugs 3 of 4
all drugs.
34
Medical
Graduate
04/27/2011

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Term
2 IV anesthetics indicated for trauma pts
Definition
thiopental/methohexital, etomidate
Term
AE of BZD vs. AE of barbituates
Definition
BZD: CNS depressant, respiratory depression, decrease PVR, anterograde amnesia
barbituates: CNS depressant, respiratory depression, no change in PVR
Term
how do you know if a BZD works as an anxiolytic, sedative, or hypnotic?
Definition
receptor occupancy; <20% anxiolytic, <50% sedative, >50% hypnotic
Term
order in terms of duration of action: lorazepam, diazepam, midazolam
Definition
diazepam > lorazepam > midazolam
Term
order in terms of potency: midazolam, diazepam, lorazepam
Definition
lorazepam > midazolam > diazepam
Term
tx for prolonged post-op sedation due to BZD
Definition
flumazenil
Term
MOA of ketamine
Definition
blocks NMDA receptor
Term
indications for ketamine
Definition
analgesia, children; asthma, hypovolemia, non ischemic cardiomyopathy, pericardial tamponade
Term
indications for etomidate
Definition
ECT, cardioconversion, trauma
Term
endocrine and CV AE of etomidate
Definition
decreases cortisol and aldosterone production; no effect on CV
Term
what 2 IV anesthetics do not cause analgesia?
Definition
etomidate, propofol
Term
what anesthetic is used for continuous infusion?
Definition
propofol
Term
what anesthetic is used as an adjuvant to decrease MAC?
Definition
opioids
Term
AE: risk of recall if used alone
Definition
opioids
Term
D2 agonists (3)
Definition
pramipexole, ropirinole, apomorphine
Term
tx for acute freezing episodes in Parkinson's
Definition
apomorphine
Term
AE: livido reticularis
Definition
amantidine
Term
MAOB inhibitor used for early Parkinson's (2)
Definition
selegiline, rasagiline
Term
indicated for dyskinesias caused by Parkinson drugs
Definition
anticholinergics: trihexyphenidyl, benztropine
Term
do not administer with SSRI or MAOi
Definition
sinemet
Term
COMT inhibitor used for late Parkinson's
Definition
entacapone
Term
why is bromocriptine not used for Parkinson's?
Definition
fibrotic complications (pleuritis, pericarditis, etc.)
Term
PD drug contraindicated in acute angle glaucoma
Definition
anticholinergics, sinemet
Term
metabolized into amphetamines; do not take at night
Definition
MAOB inhibitors rasagiline and selegiline
Term
absorbed via amino acid transporter; do not take with meals
Definition
sinemet
Term
AE of TCA
Definition
convulsions, coma, cardiotoxicity
Term
MOA of TCA
Definition
inhibits 5-HT and NE uptake; also blocks H1, H2, muscarinic Ach, and alpha2 receptors
Term
imipramine, desipramine, amytriptyline…which one is more selective for 5-HT receptors? for NE receptors?
Definition
imipramine -> 5HT; despiramine ->NE
Term
which TCA antidepressant has the least AE? worst AE?
Definition
least -> desipramine; worst -> amytriptyline
Term
MAOi used as antidepressant (2)
Definition
phenylzine, tranylcypromine
Term
2 IV anesthetics indicated for pts with asthma
Definition
ketamine, propofol
Term
2 IV anesthetics that cause pain on injection and myoclonus
Definition
etomidate, propofol
Term
AE of ketamine vs. AE of propofol
Definition

ketamine: CNS stimulant, CV stimulant, dissociative anesthesia; bronchodilator

propofol: CNS depressant, CV depressant; antiemetic; bronchodilator

Term
2 anesthetics that cause seizures
Definition
enflurane, etomidate
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