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Drug therapy osteoporosis
bisphosphonates, RANKL, PTH analog, selective estrogen modulators
6
Medical
Professional
04/02/2013

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Term
Alendronate
Definition
2nd Generation oral bisphosphonate:
1. taken up as bad atp --> apop
2. inhibits farynsel pyrophosphate syntase which builds membrane anchors

CAUSES HORRIBLE GI IRRITATION (must take in morning with watern remain up)
ACUTE PHASE RXN FEVER FOR IV
OSTEONECROSIS JAW (super rare)
ATYPICAL FEMUR FRACTURE (rare)
TERATOGEN
Contraindicated renal disease because renally eliminated

also good for bone mets!
re-eval 3-5
Term
Zoledronic Acid
Definition
3rd Generation IV bisphosphonate:
1. taken up as bad atp --> apop
2. inhibits farynsel pyrophosphate syntase which builds membrane anchors

CAUSES HORRIBLE GI IRRITATION (must take in morning with watern remain up)
ACUTE PHASE RXN FEVER FOR IV
OSTEONECROSIS JAW (super rare)
ATYPICAL FEMUR FRACTURE (rare)
TERATOGEN
Contraindicated renal disease because renally eliminated

also good for bone mets!
re-eval 3-5
Term
Denosumab
Definition
Human monoclonal antibody against RANKL
-injected sc t1/2 = weeks
-good for mets cytokins as well

1. osteonecrosis jaw
2. musculoskeltal pain (not acute rxn)
3. contra pregnant
4. INCREASES SEVERITY T-CELL INFECTION
Term
Teriparatide
Definition
PTH analog that induces osteoblast differentiation, maturation, and avoids apoptosis

1. reserved to high risk due to cost
2. contraindicated in mets and hypercalcemia (due to too long PTH)
3. may cause osteosarcoma so avoid high risk patient
dose 2-3 years only
Term
Raloxifene
Definition
Selective Estrogen Receptor Modulator
agonist bone/liver
antagonist breast (prevents cancer)
neutral uterus (no increase cancer)

1. INCREASES THROMBOEMBOLIC RISK
2. AGGREVATES CRAMPS/HOT FLASHES

good: mid osteoporosis, breast cancer
bad: stroke/DVT vasomotor spasms pregnant

mainly inhibits osteoclasts, mainly vertebral
Term
RANKL and Osteoprotegrin
Definition
RANKL- activates osteoclast
osteoprotegrin = autocrine blocker RANKL
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