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| Process where drug is taken from administration site and transported to blood stream; occurs orally, topically, rectally, parenterally, and inhalation |
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| Process that delivers drug through blood stream to specific organs and tissues to apply pharmacological effects |
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| Disappearance of a drug--changes in to another compound; takes place primarily in liver; usually enhances excretion and inactivation of a drug |
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| Process by which the drug is eliminated from the body (usually kidney); excreted via urine, feces, lungs, skin, etc. |
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| predictable and widely reported; undesired pharmacological effect of a drug seen when dose is followed; often unavoidable (e.g. nausia, drowsiness, upset stomach, addiction) |
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Effects that are harmful and destructive to body; caused by overdose, used for longer periods than recommended, or drug not properly monitored
(e.g. Chemotherapy kills ALL cells) |
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Allergic to drugs chemically similar (e.g. Penicillin and Ceflasporin) |
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| Tech should notify pharmacist; change in magnitiude or duration of pharmacological response of one drug b/c of presence of another drug |
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Possible Detrimental Effects |
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Increased risk of side effects and toxicities; decreased pharmacological response desired |
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Possible Beneficial Effects |
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Additive response; synergistic response |
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Occurs when two or more drugs combined together yield a response when the drugs were ineffective seperately |
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Occurs when the effect of two or more drugs is greater than the sum of the two drugs (2+2=4)
(e.g. Bactrim, Septra, Trimenthoprim, and Sulfamethoxazole) |
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Weigh risks v. benefits; must be done on an individual basis
(e.g. Asthma pt should not be on a B blocker, initially) |
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When a drug used for one thing causes a spike in severity of another indication
(e.g. Pseudoephendrine contraindicated in htn) |
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