Term
| What are the 4 phases of drug metabolism? |
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Definition
Phase 0: 1st pass metab
Phase I: functionalization (redox rxns)
Phase II: conjugation rxns
Phase III: drug transporter actions |
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Term
| During this phase there is some increase in polarity and high drug selectivity for particular enzymes. |
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Definition
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Term
| During this phase there is often a huge increase in polarity which prevents renal tubular reabsorption. |
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Definition
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Term
| What is the site of most drug metabolism? |
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Definition
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Term
| What is the major enzyme in Phase I (redox and hydrolysis rxns)? |
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Definition
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Term
| Why are are acetylated drugs potentially more toxic? |
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Definition
*More lipophilic therefore longer t1/2
*45% of caucasians are poor acetylators so they risk greater exposure to high drug plasma levels = toxicity
*just decrease the dose |
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Term
| Which routes by-pass first-pass metabolism? |
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Definition
*sublingual (SL)
*rectal (low)
*parenteral (SC, IV, IM)
*transdermal patches |
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