• Statin anti hyperlipidemic
• PO
• Do not take with grapefruit juice
• Rhabdomyolysis is a serious ADR

Atorvastatin

(Lipitor)

• Bile acid sequestrant (BAS)
• PO not at same time as other drugs
• Interferes with absorption of many other drugs and nutrients (including fat soluble vitamins)

Cholestyramine

(Questran)

• Fibrate
• PO before meals
• Lowers cholesterol and triglyceride levels in the blood

Gemfibrozil

(Lopid)

• Vitamin B3
• PO
• Lots of ADRs that limit compliance (flushing, hot flashes, itching, hyperglycemia, hyperuricemia, palpitations, toxic amblyopia, flatulence, diarrhea, skin pigmentation)
• 20-25% blurred vision and or dry eyes
• 10% get eyelid edema

Nicotinic Acid, Niacin

(Niacor)

• "Other" anti-hyperlipidemic
• PO

Ezetimibe

(Zetia)

• Oral anticoagulant
• PO, IV (switch to PO asap)
• Boxed warning: bleeding risk
• use requires periodic monitoring of clotting time, special diet & frequent dose adjustments. Do not take with vitamin K supplements or foods high in vitamin K.
• up to 11% get ocular hemorrhage
• warfarin-induced skin necrosis is a serious ADR
• Screen for CYP2C9 and VKORC1 activity

Warfarin

(Coumadin)

• Parenteral anti-coagulant
• Low molecular weight Heparin (LMWH) isolated from pig GIT
• SC (does not require close lab monitoring
• Boxed warning: spinal/epidural hematoma risk

Enoxaparin

(Lovenox)

• Parenteral anti coagulant
• Unfractioned Heparin (UFH) isolated from pigs and cows-highly sulfated glycosaminoglycan
• IV or deep SC requires frequent monitoring 
• Up to 50% get drug induced alopecia
• High risk of thrombocytopenia (immune-mediated)
• Supresses aldosterone causing hyperkalemia (5-10%) of patients

Heparin

(Heplock, Hepflush)

• Direct Thrombin Inhibitor anticoagulant
• PO, Prodrug
• Used to prevent clotting due to atrial fibrillation

Dabigatran

(Pradaxa)

• Parenteral anti-coagulant
• Synthetic form of anti coagulant produced by leeches (leech spit)
• 42% of patients report back ache

Bivalirudin

(Angiomax)

• NSAID
• Covalently binds to COX, permanently inhibiting COX

Aspirin

(Generics)

• ADP receptor blocker (oral antiplatelet anticoagulant), used for CAD, peripheral vascular disease and cerebrovascular disease.
• PO, prodrug
• Boxed warning: diminished effectiveness in poor metabolizers, screen for CYP2C19 function.

Clopidogrel

(Plavix)

• 3-PDE inhibitor (Oral antiplatelet anticoagulant for intermittent claudification
• PO 30 mins before or 2 hours after meals
• Boxed warnings: 3-PDE inhibitors increase the risk of death in congestive HF patients

Cilostazol 

(Pletal)

• AKA snake spit. Glycoprotein IIB/IIIA receptor blocker (IV antiplatelet anticoagulant) for acute coronary syndrome or angioplasty.
• IV only (refrigerate)

Eptifibatide

(Integrilin)

• Recombinant tissue plasmingoen activator (T-PA)- fibrinolytic for actue MI or lysis of objectively diagnosed thrombi in lungs or deep veins
• IV

• Systemic hemostatic agent (anti-fibrinolytic) to treat excess bleeding in hyperfibrinolytic states or subarachnoid hemorrhage. 
• PO, IV
• IV infusion for up to 8 hours only. 

Aminocaproic Acid

(Amicar)

• Anti-hemophilic agents (clotting factor replacement) to treat hemophilia B or factor VII and VIII deficiencies 
• IV only (refrigerate)
• obtained from pooled human plasma, so potential for blood-borne diseases (hepatitis, HIV-AIDs, and prion diseases including bovine spongiform encephalopathy or Creutzfeldt-jakob disease). Severe allergic responses possible. 

Factor IX complex

(BeneFIX)