Term
| Direct Acting Choline Esters |
|
Definition
4ary amines (do not cross BBB)
- Acetylcholine
- Carbachol |
|
|
Term
| Direct Acting Choline Alkaloids |
|
Definition
3ary amines
- Muscarine
- Pilocarpine |
|
|
Term
| Indirect Acting Cholinesterase Inhibitors |
|
Definition
DFP - disopropyl flurophosphate - IRREVERSIBLE
Neostigmine
Edrophonium iodide
Pyrdostigmine
Pesticides |
|
|
Term
| Cholinergic Muscarinic Competitive Antagonist |
|
Definition
Atropine
Homatropine
Scopolamine
Cyclopentolate
Tropicamide
Pirenzepine (AChM1 only)
-- rest are 3ary amines |
|
|
Term
| Cholinergic Nicotinic Antagonists at ANS ganglia |
|
Definition
Mecamylamine (Inversine) - C6 structure
Hexamethonium - C6 structure
d-Tubocurarine (C10 structure, AChN at skeletal muscle) |
|
|
Term
| AChN Antagonist (C10 receptors) |
|
Definition
skeletal muscle (C10) receptors blocked by -
d-tubocurarine
decamethonium
pancuronium (Pavulon) |
|
|
Term
| AChN Antagonist (C10 receptors) |
|
Definition
skeletal muscle (C10) receptors blocked by -
d-tubocurarine
decamethonium
pancuronium (Pavulon) |
|
|
Term
Direct Sympathetic Agonist
(α & B) |
|
Definition
NE - Sympathetic system
E (produced mainly by Adrenal Medulla, 80%)
Isoproterenol - mostly B |
|
|
Term
|
Definition
|
|
Term
| α2 agonist - all presynaptic inhibitors |
|
Definition
Clonidine
Guanabenz
Guanfacine |
|
|
Term
|
Definition
|
|
Term
|
Definition
Albuterol
Terbutaline
Metaproternol |
|
|
Term
| Non-selective indirect agonist that RELEASE NE |
|
Definition
ephedrine
amphetamine
hydroxyamphetamine
methyamphetamine
methylphenidate (ritalin)
tyramine
pemoline (Cylert) |
|
|
Term
| Non-selective indirect agonist that BLOCK NE-REUPTAKE |
|
Definition
Ouabain
Coccaine
Tri-methyl antidepressants (Imipramine, amytryptline)
Atomoxetine (Strattera)
S |
|
|
Term
| Non-selective indirect agonist by INHIBITING MAO-A |
|
Definition
pargyline
phenylzine (nardil)
tranylcypromine |
|
|
Term
| Non-selective indirect agonist by INHIBITING COMT |
|
Definition
|
|
Term
| Inhibit synthesis of NE/E by ENZYME INHIBITION |
|
Definition
α-methyltyrosine - inhibits tyrosine hydroxylase
Carbidopa - inhibits L-AAD
Disulfiram (Antabuse) - inhibits DBH |
|
|
Term
| Disrupts ability of vesicle to transport & store NE |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Phenoxybenzamine (Dibenzyline), Tolazoline |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Propanolol
Nadolol
Pindolol
Timolol
Levabunolol |
|
|
Term
|
Definition
Acebutolol
Atenolol
Esmolol
Metoprolol
Betoxalol |
|
|
Term
|
Definition
|
|
