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Drug Interactions
PHAR340
18
Pharmacology
Undergraduate 3
12/05/2012

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Cards

Term
Laxatives
Definition
Increased intestinal motility
Term
Tetracycline + Antacid
Definition
Drug complex is in insoluble
Term
Valproic acid
Definition
Displaces warfarin from plasma protein and increases its effect
Term
Warfarin
Definition
Displaced by valproic acid
Highly plasma protein-bound (99%)
If binding decreases by 2%, therapeutic effect is tripled
Low T.I. and small Vd
Term
Doxorubicin
Definition
Anti-cancer drug
Transported from the CNS by P-glycoprotein
Intestinal, renal tubular, biliary canalicular & blood-brain barrier cells
Term
Etoposide
Definition
Anti-cancer drug
Transported from the CNS by P-glycoprotein
Intestinal, renal tubular, biliary canalicular & blood-brain barrier cells
Term
Cyclosporin A
Definition
Inhibit PGP to increase access of anti-cancer drugs in brain
Term
Quinidine
Definition
Inhibit PGP to increase access of anti-cancer drugs in brain
Term
Verapamil
Definition
Inhibit PGP to increase access of anti-cancer drugs in brain
Term
Itraconazole
Definition
Inhibit PGP to increase access of anti-cancer drugs in brain
Term
Clarithromycin
Definition
Inhibit PGP to increase access of anti-cancer drugs in brain
Term
Cigarette smoke, barbiturates
Definition
Induction of P450 enzymes
Term
Grapefruit
Definition
Inhibition of P450 enzymes
Term
Cimetidine
Definition
Inhibition of P450 enzymes
Term
Probenecid
Definition
Acidic
Blocks anion transporter and increases half-life of penicillin
Term
Amiodarone
Definition
Basic
Blocks cation transporter to increase half-life of procainamide
Term
ASA
Excretion?
Definition
Increase excretion with base (NaHCO3)
Term
Amphetamine
Excretion?
Definition
Increase excretion with acid (NH4Cl)
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