Term
|
Definition
| Increased intestinal motility |
|
|
Term
|
Definition
| Drug complex is in insoluble |
|
|
Term
|
Definition
| Displaces warfarin from plasma protein and increases its effect |
|
|
Term
|
Definition
Displaced by valproic acid
Highly plasma protein-bound (99%)
If binding decreases by 2%, therapeutic effect is tripled
Low T.I. and small Vd |
|
|
Term
|
Definition
Anti-cancer drug
Transported from the CNS by P-glycoprotein
Intestinal, renal tubular, biliary canalicular & blood-brain barrier cells |
|
|
Term
|
Definition
Anti-cancer drug
Transported from the CNS by P-glycoprotein
Intestinal, renal tubular, biliary canalicular & blood-brain barrier cells |
|
|
Term
|
Definition
| Inhibit PGP to increase access of anti-cancer drugs in brain |
|
|
Term
|
Definition
| Inhibit PGP to increase access of anti-cancer drugs in brain |
|
|
Term
|
Definition
| Inhibit PGP to increase access of anti-cancer drugs in brain |
|
|
Term
|
Definition
| Inhibit PGP to increase access of anti-cancer drugs in brain |
|
|
Term
|
Definition
| Inhibit PGP to increase access of anti-cancer drugs in brain |
|
|
Term
| Cigarette smoke, barbiturates |
|
Definition
| Induction of P450 enzymes |
|
|
Term
|
Definition
| Inhibition of P450 enzymes |
|
|
Term
|
Definition
| Inhibition of P450 enzymes |
|
|
Term
|
Definition
Acidic
Blocks anion transporter and increases half-life of penicillin |
|
|
Term
|
Definition
Basic
Blocks cation transporter to increase half-life of procainamide |
|
|
Term
|
Definition
| Increase excretion with base (NaHCO3) |
|
|
Term
|
Definition
| Increase excretion with acid (NH4Cl) |
|
|
