Term
| Which Drugs cause Microvesicular Fat? |
|
Definition
Tetracycline
Valproic acid |
|
|
Term
| Tetracycline and valproice acid cause what kind of liver toxicity? |
|
Definition
|
|
Term
| Tetracycline and valproic acid cause macrovesicular fat in liver? T or F? |
|
Definition
| False. It is microvesicular fat |
|
|
Term
| Two drugs cause microvesicular fat in the liver? what are they? Hint T and VA |
|
Definition
| tetracycline and valproice acid |
|
|
Term
| What drugs cause Granulomatous? |
|
Definition
Diltazem,
sulfa drugs
Quinidine |
|
|
Term
| Diltiazem, Sulfa drugs, and quinidine cause what? |
|
Definition
|
|
Term
| Halothane and phenytoin and sulfamethazole cause what? |
|
Definition
| immunoallergic liver toxicity |
|
|
Term
| What drugs cause immunoallergic liver toxicity? Hint HPS |
|
Definition
Halothane
Phenytoin
Sulfamethazole |
|
|
Term
| What drugs cause hepatocellular liver toxicity? |
|
Definition
| Isoniazid, trazazone; diclofenac, lovastatin, venaflexine |
|
|
Term
| Isoniazid; trazadone; diclofenac, and lovastatin cause what kinds of liver toxicity? |
|
Definition
|
|
Term
| Amiodarone and tamoxifen cause what kinds of liver disease? |
|
Definition
|
|
Term
| what drugs cause steatohepatitis? |
|
Definition
|
|
Term
| Amiodarone and what else caue steatohepatitis? |
|
Definition
|
|
Term
| What drugs causes autoimmune hepatotoxicity? |
|
Definition
| Nitrofurantoin; Lovastatin; minocycline, |
|
|
Term
| lovastatin; nitrofurantoin and minocycline causes what? |
|
Definition
|
|
Term
|
Definition
| Autoimmune and Hepatocellular |
|
|
Term
| What drug causes both autoimmune and hepatocellular liver toxicity? |
|
Definition
|
|
Term
| Methrotrexate and excess vitamin A causes what? |
|
Definition
|
|
Term
| What kind of liver toxicity does nicotinic acid, cocaine and amphetamines cause? |
|
Definition
|
|
Term
| What drugs cause oncogenesis in the liver? |
|
Definition
| Androgens and oral contraceptives |
|
|
Term
| What drugs causes Mixed hepatic toxicity? |
|
Definition
| KAVA, Augmentin, carbamazepine, cyclosporine, trogliazone |
|
|
Term
| Kava, augmentin, carbamazepine, cyclosporine and troglitazone causes what? |
|
Definition
|
|
Term
| What two drugs have been removed from the market due to toxicity of the liver? |
|
Definition
|
|
Term
| In the past ...... years troglitazone and bromfenac have been removed from the market? |
|
Definition
|
|
Term
| Is Troglitazone causing hepatic failure believed to be a class effect of thiazolidnediones? |
|
Definition
|
|
Term
| Drugs account for what percentages of hepatic failure in teh elderly? |
|
Definition
|
|
Term
| What is Phase I metabolism |
|
Definition
Oxidation and demethylation.
Cytocrhrom P450 |
|
|
Term
| What are Phase II enzyems? |
|
Definition
conjugation;
covalent bonds and glucuronic acid and sulfate and glutathione |
|
|
Term
| Is CP450 Phase I or phase II? |
|
Definition
|
|
Term
| REduction; oxidation, and hydrolysis are a part of this kind of metabolism |
|
Definition
|
|
Term
| When the enzymes are esterases and causes esters the metabolism is what? |
|
Definition
|
|
Term
| Could Hydrolysis also be phase III? |
|
Definition
|
|
Term
| Acetaminophen is intrinsic or idosyncratic toxicity? |
|
Definition
|
|
Term
| Describe intinsic hepatotocity |
|
Definition
Dose dependent; predictable; slow onset and long duration; respond to lowering offending agent.
Often associated with genetic or acquired abnormality in metabolic pathway |
|
|
Term
| If you have intrinsic hepatotoxicity do you have to totally take the person off of the drug? |
|
Definition
|
|
Term
|
Definition
| Immune mediated reactive metabolites |
|
|
Term
| Idiosyncratic actually destroys liver cells? true or F? |
|
Definition
|
|
Term
| Disruption of actin filaments causes what? |
|
Definition
| It causes an effect on bile excretion to cause drug accumulation |
|
|
Term
| When you damage MRP(3) a transport protein via idiosyncratic causes what is the effect on bile and hepatotoxins? |
|
Definition
| prevent the excretion of them so there is drug accumulation. |
|
|
Term
What does zonal hepatic injury mean?
What does non zonal hepatic injury mean? |
|
Definition
Zonal is limited to specific zones.
Nonzonal means to diffuse the injury. |
|
|
Term
| Idiosyncratic is likely to cause zonal or non z0nal? |
|
Definition
non zonal...
Immune mediated injury causes zonal |
|
|
Term
| for idiosyncratic must the offending agent be removed to resolve/ |
|
Definition
|
|
Term
| what are enzymes responsible for metabolic idosyncrasy? |
|
Definition
|
|
Term
| CYP1A2 and CYP2C9 are responsible for intrinic or idosyncratic? |
|
Definition
|
|
Term
| What are the liver marers for Idiosyncratic rxns? |
|
Definition
LKM and LM
LKM targets anti liver kidney microsomial
LM is anti liver microsomal; targets cyp1a2 |
|
|
Term
| What doesLKM target? What does LM target? |
|
Definition
LKM targets cyp2c9
lm targets 1A2 |
|
|
Term
| Does ALK Phos increase in Liver disease? |
|
Definition
|
|
Term
| Nitrofurantoin; methyldopa; and antituberculosis drugs can cause necroinflammatory disease? yes!!! |
|
Definition
|
|
Term
| Do microvesicular or macrovesicular displace hepatocyte nucleus? |
|
Definition
|
|
Term
| Steatosis Presentation. When you have AST and ALT 20 time above normal and bilirubin 10 times above normal and alkaline 2 time above normal... is it macrovsesicular or micro? |
|
Definition
| Micro. Macro have increases that are 4 times less than micro. |
|
|
Term
| Can steatosis cause pancreatitis? |
|
Definition
|
|
Term
What drugs cause microvesicular steatosis?
Ethanol; glucocorticoids; Methotrexate |
|
Definition
|
|
Term
| What drugs cause macrovesicular steatosis? |
|
Definition
| Asparaginase; valproate; amiodarone |
|
|
Term
| Macrovesicular steatosis always cause necrosis? |
|
Definition
|
|
Term
What drugs cause macrovesicular disease?
Asparaginase; valproate; amiodarone |
|
Definition
|
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