Term
| The generic name for Tenormin is: |
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Definition
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Term
| Atenolol is in this therapeutic class(es): |
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Definition
| SympathoLYTIC; antihypertensive |
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Term
| Atenolol is in this pharmacologic class: |
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Definition
| Beta-1 receptor antagonist (Beta-1 blocker) |
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Term
|
Definition
| Competitively inhibits Beta-1 receptors |
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Term
| Atenolol is used clinically to treat: |
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Definition
| Angina, hypertension, post-MI cardioprotection |
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Term
| Adverse effects of atenolol include: |
|
Definition
| Bronchoconstriction with higher doses because of Beta-2 receptor blockade |
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Term
| Rx-Rx interactions with atenolol: |
|
Definition
1. Additive hypotensive effect with nitrates and antihypertensive drugs
2. Additive bradycardia with digoxin
3. Decreases effects of dopamine and dobutamine |
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Term
| The generic name for Atro-Pen is: |
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Definition
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Term
| Atropine belongs to this therapeutic class: |
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Definition
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Term
| Atropine is in this pharmacologic class: |
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Definition
| Muscarinic receptor antagonists |
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Term
|
Definition
| Competitively inhibits all muscarinic receptors |
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Term
| Atropine is used clinically to treat: |
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Definition
| Bradycardia and atrioventricular block; IBS; anticholinesterase poisoning; antisecretory agent |
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Term
| Adverse effects of atropine include: |
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Definition
| Tachycardia; mydriasis and cycloplegia; warm, dry, flushed skin; delirium; hallucinations |
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Term
| Rx-Rx interactions with atropine: |
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Definition
1. Additive anticholinergic effects with antihistamines (e.g. diphenhydramine)
2. Additive anticholinergic effect with tricyclic antidepressants (e.g. amitriptyline)
3. Slows absorption of other drugs by delaying gastric emptying |
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Term
| The generic name for Dobutrex is: |
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Definition
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Term
| Dobutamine belongs to this therapeutic class: |
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Definition
| SympathoMIMETIC; cardiac stimulant |
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Term
| Dobutamine belongs to this pharmacologic class: |
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Definition
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|
Term
|
Definition
| Activates Beta 1 > Beta 2 >> Alpha 1 receptors; increases cardiac contractility and cardiac output > heart rate |
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Term
| Dobutamine is clinically used to treat: |
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Definition
| Acute heart failure and cardiogenic shock |
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Term
| Adverse effects of dobutamine include: |
|
Definition
| Tachycardia and arrhythmia |
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Term
| Rx-Rx interactions with dobutamine: |
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Definition
| Synergistic effect on cardiac output with nitroprusside |
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Term
| The generic name of Tensilon is: |
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Definition
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Term
| Edrophonium belongs to this therapeutic class: |
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Definition
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Term
| Edrophonium belongs to this pharmacologic class: |
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Definition
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Term
|
Definition
| Reversibly binds and inhibits cholinesterase |
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Term
| Edrophonium is clinically used for: |
|
Definition
| Diagnosis of myasthenia gravis; differential diagnosis of myasthenic crisis and cholinergic crisis |
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Term
| Adverse effects of edrophonium include: |
|
Definition
| Muscarinic effects (e.g. SLUDGE, miosis, etc) |
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Term
| The generic name for Adrenalin is: |
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Definition
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Term
| Epinephrine belongs to this therapeutic class: |
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Definition
| SympathoMIMETIC; bronchodilator; vasopressor |
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Term
| Epinephrine belongs to this pharmacologic class: |
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Definition
| Nonselective adrenergic agonist |
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Term
|
Definition
Activates Alpha (a) and Beta (B) receptors increasing IP3 and cAMP:
a1: Vasoconstriction and increased blood pressure
B1: Increased heart rate, conduction, and contractility
B2: Vasodilation and decreased diastolic blood pressure; bronchodilation |
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Term
| Epinephrine is clinically used to treat: |
|
Definition
| Cardiac arrest; ventricular fibrillation; anaphylactic shock; asthma; COPD |
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Term
| Epinephrine adverse effects include: |
|
Definition
| Hypertension; tachycardia; ischemia; hyperglycemia |
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Term
| The generic name for Dibenzyline is: |
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Definition
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Term
| Phenoxybenzamine belongs to this therapeutic class: |
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Definition
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Term
| Phenoxybenzamine belongs to this pharmacologic class: |
|
Definition
| Irreversible Alpha receptor antagonist |
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Term
|
Definition
| Inhibits Alpha-1 > Alpha-2 receptors |
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Term
| Phenoxybenzamine is used clinically for: |
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Definition
| Presurgical treatment of hypertension caused by pheochromocytoma |
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Term
| Phenoxybenzamine adverse effects includes: |
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Definition
|
|
Term
| Rx-Rx interactions with phenoxybenzamine include: |
|
Definition
| Hypotensive effect increased by beta blockers (e.g. atenolol) and calcium channel blockers (e.g. amlodipine, diltiazem, verapamil) |
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Term
| The generic name for Regitine is: |
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Definition
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Term
| Phentolamine belongs to this therapeutic class: |
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Definition
|
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Term
| Phentolamine belongs to this pharmacologic class: |
|
Definition
| Alpha-receptor antagonist |
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|
Term
|
Definition
| Competitively inhibit alpha-1 and alpha-2 receptors (Non-selective, competitive inhibition of alpha receptors) |
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Term
| Phentolamine is used clinically: |
|
Definition
| To counteract vasoconstriction caused by accidental injection or extravasation of vasoconstrictors; control of blood pressure during surgical removal or a pheochromocytoma |
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Term
| Adverse effects of phentolamine include: |
|
Definition
|
|
Term
| Rx-Rx interactions of phentolamine include: |
|
Definition
1. Severe hypotension if given with epinephrine
2. Blocks effects of alpha-adrenergic agonists |
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Term
| The generic name for Neo-Synephrine is: |
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Definition
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Term
| Phenylephrine belongs to this therapeutic class: |
|
Definition
| Vasoconstrictor; decongestant |
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Term
| Phenylephrine belongs to this pharmacologic class: |
|
Definition
| Selective alpha-1 receptor agonist |
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|
Term
|
Definition
| Activates alpha-1 receptors, increasing IP3 and causing contraction of vascular smooth muscle |
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Term
| Phenylephrine is clinically used: |
|
Definition
| Nasal and ocular decongestant; treatment of drug-induced hypotension and spinal shock; dilation of pupil for ophthalmoscopy |
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Term
| Adverse effects of phenylephrine include: |
|
Definition
| Rebound nasal congestion; hypertension |
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Term
| Rx-Rx interactions for phenylephrine include: |
|
Definition
1. Severe hypertension if given with MAOIs
2. Vasopressor effect increased by tricyclic antidepressants |
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Term
| The generic name for Salagen is: |
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Definition
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Term
| Pilocarpine belongs to this therapeutic class: |
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Definition
| Antiglaucoma agent; sialagogue |
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Term
| Pilocarpine belongs to this pharmacologic class: |
|
Definition
| Muscarinic receptor agonist |
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|
Term
|
Definition
| Activates muscarinic receptors in ciliary muscle, increase aqueous humor outflow; activates muscarinic receptors in salivary gland, increasing salivation |
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Term
| Pilocarpine is used clinically: |
|
Definition
| To treat glaucoma and dry mouth (xerostomia) |
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Term
| Adverse effects of pilocarpine include: |
|
Definition
| Miosis, blurred vision (accommodative spasm) |
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|
Term
| Rx-Rx interactions of pilocarpine include: |
|
Definition
1. Additive effects with other cholinergic drugs
2. Effects decreased by atropine and other anticholinergic drugs |
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Term
| What is the generic name for Protopam? |
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Definition
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Term
| Pralidoxime belongs to this therapeutic class: |
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Definition
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Term
| Pralidoxime belongs to this pharmacologic class: |
|
Definition
| Cholinesterase reactivator |
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Term
|
Definition
| Binds phosphorus of organophosphate and breaks organophosphate bond with cholinesterase |
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Term
| Pralidoxime is clinically used: |
|
Definition
| Treatment of organophosphate toxicity (reverses muscle weakness) |
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Term
| Adverse effects of pralidoxime include: |
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Definition
| When treating organophosphate poisoning it is difficult to differentiate the toxic effects of pralidoxime from those produced by atropine or organophosphate compounds |
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Term
| Rx-Rx interactions for pralidoxime include: |
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Definition
| When used with atropine, signs of atropinization occur earlier than when atropine is used alone |
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Term
| The generic name for Inderal is: |
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Definition
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Term
| Propranolol belongs to this therapeutic class: |
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Definition
| Sympatholytic; antihypertensive |
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Term
| Propranolol belongs to this pharmacologic class: |
|
Definition
| Nonselective beta-receptor antagonist |
|
|
Term
|
Definition
| Competitively inhibits beta-1 and beta-2 receptors |
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|
Term
| Propranolol is used clinically to treat: |
|
Definition
| Angina; hypertension; post-MI; cardiomyopathy; benign tremor; migraine prophylaxix; thyrotoxicosis |
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Term
| Adverse effects of propranolol include: |
|
Definition
| Bronchoconstriction; inhibits glycogenolysis; nightmares and mood depression |
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|
Term
| Rx-Rx interactions for propranolol include: |
|
Definition
1. Additive hypotensive effect with nitrates and antihypertensive drugs
2. Additive bradycardia with digoxin
3. Decreases effects of dopamine and dobutamine
4. Unopposed alpha-adrenergic receptor stimulation with epinephrine and related drugs |
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Term
| The generic name for Sudafed is: |
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Definition
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Term
| Pseudoephedrine belongs to this therapeutic class: |
|
Definition
|
|
Term
| Pseudoephedrine belongs to this pharmacologic class: |
|
Definition
| Indirect- and direct-acting adrenergic receptor agonist |
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|
Term
|
Definition
| Increases release of norepinephrine and directly activates adrenergic receptors, causing vasoconstriction and cardiac stimulation |
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Term
| Pseudoephedrine is used clinically: |
|
Definition
| Nasal decongestant for allergic and viral rhinitis |
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Term
| Adverse effects of pseudoephedrine include: |
|
Definition
| Tachycardia; increased blood pressure; CNS stimulation |
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Term
| Rx-Rx interactions for pseudoephedrine include: |
|
Definition
| Concurrent use with MAOIs may cause severe hypertension |
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Term
| The generic name for Mestinon is: |
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Definition
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|
Term
| Pyridostigmine belongs to this therapeutic class: |
|
Definition
|
|
Term
| Pyridostigmine belongs to this pharmacologic class: |
|
Definition
| Cholinesterase inhibitor; cholinergic agonist |
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|
Term
|
Definition
| Reversibly inhibits cholinesterase |
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Term
| Pyridostigmine is used clinically: |
|
Definition
| Treatment of myasthemia gravis; reversal of nondepolarizing neuromuscular blockers (curaiform drugs) |
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Term
| Adverse effects of pyridostigmine include: |
|
Definition
| Muscarinic effects (e.g., miosis, salivation, etc.) |
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Term
| Rx-Rx interactions for pyridostigmine include: |
|
Definition
1. Prolongs effects of succinylcholine
2. Effects reduced by atropine, antidepressants, phenothiazine drugs, quinidine, and other drugs with anticholinergic effects |
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Term
| The generic name for Zemuron is: |
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Definition
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|
Term
| Rocuronium belongs to this therapeutic class: |
|
Definition
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Term
| Rocuronium belongs to this pharmacologic class: |
|
Definition
| Nondepolarizing neuromuscular blocking agent |
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|
Term
|
Definition
| Competitively inhibits nicotinic receptors in skeletal muscle |
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Term
| Rocuronium is used clinically: |
|
Definition
| Skeletal muscle relaxation for intubation, surgery, and electroconvulsive therapy |
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Term
| Adverse effects of rocuronium include: |
|
Definition
| Respiratory muscle paralysis and apnea |
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Term
| Rx-Rx interactions for rocuronium include: |
|
Definition
| Effects potentiated by anesthetics, calcium channel blockers, tetracycline, and aminoglycoside antibiotics |
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Term
| The generic name for Viagra is: |
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Definition
|
|
Term
| Sildenafil belongs to this therapeutic class: |
|
Definition
|
|
Term
| Sildenafil belongs to this pharmacologic class: |
|
Definition
| Phosphodiesterase inhibitor (PDEI) |
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|
Term
|
Definition
| Inhibits type 5 phosphodiesterase and degradation of cGMP, thereby increasing vasodilation in corpus cavernosum evoked by ACh released from sacral parasympathetic neurons |
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Term
| Sildenafil is used clinically: |
|
Definition
| Treatment of erectile dysfunction |
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Term
| Adverse effects of sildenafil include: |
|
Definition
| Headache; nasal congestion; back pain; visual disturbances |
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|
Term
| Rx-Rx interactions for sildenafil include: |
|
Definition
1. Potentiates vasodilation produced by organic nitrates
2. Concurrent use with organic nitrates can cause reflex tachycardia, angina, and death from myocardial ischemia
3. Serum levels increased by CYP 3A4 inhibitos |
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Term
| The generic name for Anectine is: |
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Definition
|
|
Term
| Succinylcholine belongs to this therapeutic class: |
|
Definition
|
|
Term
| Succinylcholine belongs to this pharmacologic class: |
|
Definition
| Depolarizing neuromuscular block |
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|
Term
|
Definition
| Binds to nicotinic receptors, causing prolonged depolarization of skeletal muscle and paralysis |
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Term
| Succinylcholine is used clinically: |
|
Definition
| Short-term skeletal muscle relaxation for intubation and surgery |
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Term
| Adverse effects of succinylcholine include: |
|
Definition
| Respiratory muscle paralysis and apnea, especially in persons with rare atypical cholinesterase |
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|
Term
| Rx-Rx interactions for succinylcholine include: |
|
Definition
| Neuromuscular blockade enhanced by aminoglycoside antibiotics, clindamycin, amphotericin B, quinidine, and cholinesterase inhibitors |
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Term
| The generic name for Flomax is: |
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Definition
|
|
Term
| Tamsulosin belongs to this therapeutic class: |
|
Definition
|
|
Term
| Tamsulosin belongs to this pharmacologic class: |
|
Definition
| Uroselective adrenergic alpha-1 antagonist |
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|
Term
|
Definition
| Competitively blocks alpha-1a receptors in prostate |
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|
Term
| Tamsulosin is used clinically: |
|
Definition
| Treatment of urinary outflow obstruction in men with benign prostatic hyperplasia |
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|
Term
| Adverse effects of tamsulosin include: |
|
Definition
| Dizziness; headache; postural hypotension |
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|
Term
| Rx-Rx interactions for tamsulosin include: |
|
Definition
| Cimetidine may increase blood levels and effects |
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|
Term
| The generic name for Hytrin is: |
|
Definition
|
|
Term
| Terazosin belongs to this therapeutic class: |
|
Definition
| Antihypertensive agent; urologic agent |
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|
Term
| Terazosin belongs to this pharmacologic class: |
|
Definition
| Selective alpha-1 antagonist |
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|
Term
|
Definition
| Competitively blocks alpha-1 receptors |
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|
Term
| Terazosin is used clinically: |
|
Definition
| Treatment of hypertension; treatment of outflow obstruction in men with benign prostatic hyperplasia |
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|
Term
| Adverse effects of terazosin include: |
|
Definition
| Hypotension; "first-dose" syncope |
|
|
Term
| Rx-Rx interactions for terazosin include: |
|
Definition
| Additive hypotensive effect with diuretics and other antihypertensive drugs |
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