Term
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Definition
| Competes with penicillin for anionic renal transporter |
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Term
|
Definition
| Eliminated by renal clearance |
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Term
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Definition
| Eliminated by renal clearance |
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Term
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Definition
First-order elimination by glomerular filtration
GFR = 130 ml/min
Freely filtered, not bound to plasma protein
Rate increases with [drug] at constant rate
μg/ml x ml/min = μg/min |
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Term
Acetylsalicylic acid (ASA, aspirin)
Dose regiment? |
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Definition
Dose regiment is dependent on desired therapeutic effect
Low dose → analgesic effect
High dose → anti-inflammatory effect |
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Term
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Definition
Zero order kinetics at ADH enzyme saturation
Pseudo-first order until concentration is low
Rate is constant with further increase in [drug]
10ml/hour, 1 drink is 17ml |
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