______ + tetracycline

• Effect drug binding in the GI tract
• tetracycline binds to the divalent cations of _______ (aluminum and calcium) forming an insoluble complex

increase in renal blood flow effecting excretion of digoxin 

increases the renal clearance of digoxin

_______ treats high blood pressure by relaxing blood vessels so blood can flow more easily through the body 

a drug used to treat congestive heart failure by slowing the heart beat. 

drug interaction along with hydralazine, which  increases renal blood flow leading to faster renal clearance of this drug

______+ Penicillin

Inhibition of active tubular secretion 

______competitively inhibits the excretion of Penicillin

this makes penicillin more effective

________ + Probenecid 

Inhibition of active tubular secretion 

probenecid prolongs the half-life of _______, allowing single dose therapy

______ + antacids 

Alterations in tubular reabsorption 

(_____ is not reabsorbed because of the antacid raising the pH of the urine, ___ is excreted)

______ + Acetaminophen

Additive effect

the combined effect of the two drugs giving the same response by the SAME MECHANISM 

inhibits the enzyme responsible for the metabolism of Theophylline 

__________ reduces the metabolism of theophylline (by inhibition of CYP450 isozymes) causing an accumulation in theophylline levels

Metabolism enzyme induction 

_____________ increases the metabolism of warfarin, resulting in reduced anticoagulation

Metabolism interaction with Phenobarbital (enzyme Induction) leads to less _____ in circulation because it is metabolized faster 

Distribution interaction:

Phenylbutazone displaces ______ from plasma binding sites. as a result more _____ is free in circulation 

an NSAID no longer used in humans that displaces warfarin from plasma binding sites

this is an example of a distribution interaction: displacement from tissue binding sites/proteins