Term
| MOA of Actonel (risedronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Didronel (etidronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Fosamax (alendronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Aredia (pamidronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Boniva (ibandronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Skelid (tiludronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Bonefos (clodronate)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Reclast (zoledronic acid)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Zometa (zoledronic acid)? |
|
Definition
| bisphosphonates: inhibit formatn and activities of osteoclasts via inhibition of certain compds/proteins |
|
|
Term
| MOA of Evista (raloxifene)? |
|
Definition
| SERMs (selective estrogens receptors modulators): ↓resorption, ↑bone building |
|
|
Term
| MOA of Cibacalcin (calcitonin human)? |
|
Definition
| ↓resorption, ↓(total # of osteoclasts) |
|
|
Term
| MOA of Miacalcin (calcitonin salmon)? |
|
Definition
| ↓resorption, ↓(total # of osteoclasts) |
|
|
Term
| MOA of Fortical (calcitonin salmon)? |
|
Definition
| ↓resorption, ↓(total # of osteoclasts) |
|
|
Term
| MOA of Calcimar (calcitonin salmon)? |
|
Definition
| ↓resorption, ↓(total # of osteoclasts) |
|
|
Term
| MOA of Premarin (estrogens conjugated)? |
|
Definition
| ↑Estrogen→↑OPG(OsteoProteGerin: inhibitor of RANKL)→↓RANKL→↓Resorption |
|
|
Term
| MOA of Cenestin (estrogens conjugated, A)? |
|
Definition
| ↑Estrogen→↑OPG(OsteoProteGerin: inhibitor of RANKL)→↓RANKL→↓Resorption |
|
|
Term
| MOA of Enjuvia (estrogens conjugated, B)? |
|
Definition
| ↑Estrogen→↑OPG(OsteoProteGerin: inhibitor of RANKL)→↓RANKL→↓Resorption |
|
|
Term
| MOA of Menest (esterified estrogen)? |
|
Definition
| ↑Estrogen→↑OPG(OsteoProteGerin: inhibitor of RANKL)→↓RANKL→↓Resorption |
|
|
Term
| MOA of Prempro (premarin+medroxyprogesterone(MDPG))? |
|
Definition
|
|
Term
| MOA of Premphase (premarin+medroxyprogesterone(MDPG))? |
|
Definition
|
|
Term
| MOA of Testred (methyltestosterone)? |
|
Definition
|
|
Term
| MOA of Forteo (teriparatide)? |
|
Definition
| intermitting, bolus dose of PTH: ↑osteoblast |
|
|
Term
| MOA of Xgeva (denosumab)? |
|
Definition
| Monoclonal antibodies (Mabs): RANKL inhibition |
|
|
Term
| MOA of Prolia (denosumab)? |
|
Definition
| Monoclonal antibodies (Mabs): RANKL inhibition |
|
|
Term
| MOA of Delta-D (cholecalciferol)? |
|
Definition
| Vitamin D3 derivative: after cleavage of C9 and C10 bond |
|
|
Term
| MOA of Calderol (calcidiol)? |
|
Definition
| Vitamin D3 derivative: after hydroxylation of C25 in the liver |
|
|
Term
| MOA of Rocaltrol (calcitriol)? |
|
Definition
| Vitamin D3 active: after dual hydroxylation of C25, and C1 (in the kidney) |
|
|
Term
| MOA of Calcijex (calcitriol)? |
|
Definition
| Vitamin D3 active: after dual hydroxylation of C25 (in the liver), and C1 (in the kidney) |
|
|
Term
| MOA of Dovonex (calcipotriene)? |
|
Definition
| Vitamin D3 analog of calcitriol |
|
|
Term
| MOA of Hectorol (doxercalciferol)? |
|
Definition
| Vitamin D2 analog: only need to be hydroxylated in the liver |
|
|
Term
| MOA of Zemplar (paricalcitol)? |
|
Definition
| Vitamin D2 analog: already activated at C1 and C25 |
|
|
Term
| MOA of Calciferol (ergocalciferol)? |
|
Definition
| Vitamin D2 analog: produced from pro-vitamin D2 - ergosterol (after UV light cleavage) |
|
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