Term
| Nucleoside and Nucleotide for Adenine |
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Definition
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Term
| Nucleoside and Nucleotide for Guanine |
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Definition
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Term
| Nucleoside and Nucleotide for Uracil |
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Definition
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Term
| Nucleoside and Nucleotide for Cytosine |
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Definition
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Term
| NSide and NTide for Adenine in DNA |
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Definition
| Deoxyadenosine, Deoxyadenylate |
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Term
| NSide and NTide for Guanine in DNA |
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Definition
| Deoxyguanosine, Deoxyguanylate |
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Term
| NSide and NTide for Thymine in DNA |
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Definition
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Term
| NSide and NTide for Cytosine in DNA |
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Definition
| Deoxycytidine, Deoxycytidylate |
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Term
| Nucleotides produced by small simple molecules until later synthesized |
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Definition
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Term
| Reusing already made bases. Ex: AMP produced by de novo synthesis produces Adenine, which can later be reused to make AMP |
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Definition
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Term
| This is essential for the synthesis of both purine and pyrimidine nucleotides |
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Definition
| PRPP 5-Phosphoribosyl-1-pyrophosphate |
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Term
| Main organ where nucleotides are sequenced de novo |
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Definition
| Liver. Also occurs in brain, lymphocytes, and erythroid cells |
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Term
| Where does salvage pathway occur |
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Definition
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Term
| Most important enzyme in the synthesis of purine nucleotides |
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Definition
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Term
| Overall strategy of de novo synthesis of purine nucleotides |
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Definition
| Purine ring is assembled on ribose sugar and IMP is formed as the intermediate which then is converted into AMP and GMP |
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Term
| How AMP is reduced to Uric Acid |
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Definition
| AMP-->Remove Phosphate-->Adenosine-->Inosine-->remove ribose-->Hypoxanthine-->oxidize-->Xanthine-->Oxidized--UA |
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Term
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Definition
| GMP-->Remove P-->Guanosin-->Remove Ribose-->Guanine-->Oxidized-->Xanthine-->Uric Acid |
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Term
| Reaction catalyzed by HRPT in purine salvage (Hypoxanthine guanine phosphoribosyl transferase |
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Definition
Hypoxanthine+PRPP-->IMP+PPi
and
Guanine+PRPP-->GMP+PPi |
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Term
| Reaction catalyzed by ARPT Adenine Phosphoribosyl transferase in purine salvage |
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Definition
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Term
| End product of purine metabolism |
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Definition
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Term
| This enzyme removes the amino group from the Adenine base for the hypoxanthine |
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Definition
| Adenosine Deaminase (ADA) |
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Term
| Produces xanthine from hypoxanthine and uric acid from xanthine |
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Definition
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Term
| In purine the first thing to be synthesized is the |
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Definition
| Ribose-5-Phosphate then the base |
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Term
| In pyrimidines the first things synthesized is the |
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Definition
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Term
| All enzymes for purine synthesis are present in the |
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Definition
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Term
| All enzymes for pyrmidine synthesis are present in the |
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Definition
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Term
| Precursor for the synthesis of nucleotides containing cytosine and thymine |
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Definition
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Term
| Three enzymes found on same trifunctional enzyme (CAD) that work with pyrimidine synthesis |
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Definition
| Carbamoylphophate synthetase, Aspartate transcarbamoylase, Dihydroorotase |
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Term
| Carbamoylphosphate Synthetase II is a cytosolic enzyme that synthesizes what reaction |
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Definition
| CO2+Glutamine+2ATP-->Carbamoylphosphate +2ADP+Glutamate |
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Term
| Aspartate transcarbamoylase is a cytosolic enzyme that synthesizes |
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Definition
| Carbamoylase+Aspartate-->Carbamoylase +Pi |
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Term
| Dihydroorotase is a cytosolic enzyme that |
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Definition
| Carbamoylaspartate-->Dihydroorotate +H2O |
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Term
| Dihydroorotate-->Orotate by what enzyme |
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Definition
| Dihydroorotate dehydrogenase( Mitochondrial Enzyme) |
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Term
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Definition
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Term
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Definition
| Orotate phosphoribosyl transferase (cytosolic) |
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Term
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Definition
| OMP decarboxylase (cytosolic enzyme) |
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Term
| Present on bifuntional enzyme UMP synthase |
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Definition
| Orotate phosphoribosyl transferase & OMP decarboxylase |
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Term
| Converts a Nucleoside DiPhosphate into deoxynucleotide |
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Definition
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Term
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Definition
| UMP-->UDP-->UTP-->UTP =Glutamine+ATP-->CTP+Glutamate+ADP+Pi |
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Term
| Only nucleotide syntesized directly as deoxyribonucleotide |
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Definition
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Term
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Definition
| UDP+NADPH+H+-->dUDP+NADP+H20 (Ribonucleotide reductase) dUDP-->dUMP-->dUMP +N5,N10-Methylenetetrahydrofolate-->TMP+Dihydrofolate (Thymidylate synthase) |
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Term
| Differences between Carbamoylphosphate synthetase II and I (CPS II and CPSI I) |
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Definition
CPS II is present in more cells
CPS I predominantly in liver
CPSII Cytosolic enzyme
CPSI Mitochondrial enzyme
CPS II pyrimidine synthesis
CPS I urea synthesis
CPS I glutamine as amino donor
CPS I ammonium ion as amino donor |
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Term
| Ammonia toxicity leads to |
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Definition
| Elevated Levels of orotic acid in urine, orotate acid rise |
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Term
| Required enzyme for the conversion of dUMP into TMP |
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Definition
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Term
| Characterized by elevated plasma levels |
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Definition
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Term
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Definition
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Term
| Rate limiting step in Pyrimidine biosynthesis |
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Definition
| Aspartate transcabamoylase |
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