Term
| General characteristics of Gout |
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Definition
Usually affect men older than 25 and women who are post-menopausal
Initial presentation is usually a painful attack of monoarticular arthritis
Various precipitating factors (trauma, alcohol, surgery, diet, drugs) |
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Term
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Definition
| May be inherited as idiopathic or secondary to a defect in purine metabolism leading to an overproduction of uric acid |
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Term
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Definition
| May be the result of an inherited disorder (Lesch-Nyhan or glycogen storage) or the result of over production due to an increase in cellular turnover or under secretion |
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Term
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Definition
Crystal arthropathies
Infection
Sarcoidosis
Trauma
Aseptic joint
Cellulitis |
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Term
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Definition
Pain of the involved joint
Redness
Swelling
Mild fever and chills |
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Term
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Definition
Asymptomatic Hyperuricemia
Acute Gouty Arthritis
Intercritical Gout
Chronic Tophaceous Gout |
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Term
| Asymptomatic Hyperuricemia |
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Definition
| High uric acid - have not yet had an acute attack |
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Term
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Definition
Have had an acute attack - hot red swollen joint
Sx present but blood work (uric acid) is normal - can be misleading (though they do have uric acid crystals in the joint) |
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Term
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Definition
Patient has already had an acute gouty flareup
High uric acid content but no Sx |
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Term
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Definition
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Term
| Criteria for the Dx of acute gout |
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Definition
A - The presence of characteristic urate crystals in the joint fluid
B - A tophus proved to contain urate crystals by chemical means or polarized light microscope
Presence of 6 of 12 clinical, laboratory and radiographic phenomena |
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Term
| Most commonly affected joint in Gout |
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Definition
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Term
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Definition
NSAIDs and Colchicine - 1st line
Corticosteroids and analgesics |
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Term
| Causes of sustained Hyperuricemia |
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Definition
Alcohol consumption
Exercise - cellular turnover
Fructose consumption
High purine intake
Myeloproliferative disorders
Obesity and hypetriglyceridemia |
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Term
| Drugs used in long term management of Gout |
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Definition
Allopurinol
Probenecid
Sulfinpyrazone |
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