Term
| What are the exclusions for extended interval dosing for AGs? |
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Definition
Cystic fibrosis
Gram-positive synergy (including endocarditis)
Pregnancy
Acute burn injury (<48h since thermal injury)
Dialysis
Unstable renal function
Mycobacterial infections |
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Term
| What is the Hartford Nomogram? |
|
Definition
| 7mg/kg of gentamycin/tobramycin |
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Term
| What are the initial dosing intervals for the Hartford nomogram? |
|
Definition
CrCl > 60 = 24h
CrCl 40-59 = 36h
CrCl 20-39 = 48h
CrCl <20 = give as needed (trough less than 1) |
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|
Term
|
Definition
0.26L/kg
0.35L/kg for cystic fibrosis |
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Term
| What is the Vd of AGs when the patient has cystic fibrosis? |
|
Definition
|
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Term
| When dosing AG, what do you use for body weight? |
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Definition
For CrCl, if BW is less than IBW, use ABW. Only use aBW if the patient is greater than 30% above IBW.
Use the same weight for Vd calculations. |
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