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Dosing Adjustments and Other Drugs
Therapy Final
9
Pharmacology
Professional
12/09/2012

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Cards

Term
Mesna
Definition
Drug to bind the acreolin that builds up when taking nitrogen mustard (specifically ifosfamide)
Term
Dexrazoxane
Definition
Iron chelator to deal with anthracycline toxicity
Term
leucovorin
Definition
used to help prevent and decrease toxicity of methotrexate
Term
bevaczimumab
Definition
used in combo with chemo for advanced NSCLC
Term
Dexamethasone, folic acid, and B12
Definition
adjuvent medications necessary for pemetrexed
Term
drugs that need Hepatic dosing adjustment
Definition
anti-microtubules (taxanes, vinca alkyloids), anthracyclines, etoposide, tenoposide, irinotecan
Term
drugs that need Renal adjustment
Definition
alkylating agents, antimetabolites, anti-tumor (Bleomycin,mitomycin), etoposide, tenoposide, topetocan
Term
anthracyclines
Definition
cumulative lifetime dosing 450-550mg/m2 (doxo, dauno-rubacin) and epirubacin 900mg/m2
Term
folate antagonists
Definition
renal adjustment for CrCl < 50ml/min
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