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Dosage Forms and Routes of Admin
Dosage and routes of admin
67
Pharmacology
Undergraduate 1
03/19/2014

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Term
Dosage Form
Definition
System or device for delivering the drug to the body.
Term
Additives
Definition
Additional formulation aids that may be necessary for a successful preparation of a dosage form.
Term
Diluents
Definition
Additives used to increase the bulk weight or volume of a dosage form. Easier handled by patient.
Term
Excipients
Definition
Inactive substances used as a carrier for the active ingredients of a medication.
Term
Preservatives
Definition
Substances that retard, minimize, or prevent the growth of bacteria or other microorganism in the dosage form.
Term
Solid Dosage Form Types
Definition
Tablets, suppositories, lozenges, powders and granules
Term
Solid dosage forms advantages
Definition

Increased stability, shelflife

ease of packaging, storage, dispensing, and transport

accurate dosing

controlled release

self administration

little to no taste or smell, in most cases.

Term
Capsules
Definition

Drug is enclosed in a gelatin shell

dissolves in stomach after 10-30 min

size ranges from 000 (largest) to 5 (smallest)

000 is usually not able to be swallowed contents are sprinkled over food.

can be solid gelatin or flexible caps

come in many color making them popular

Term
Tablet types
Definition
Chewable, Enteric-coated (EC), Sublingual, Buccal, Film-coated, Effervescent, Pellets, and Vaginal.
Term
Lozenges
Definition
Hard, Oval, or discoid solid dosage form
Dissolve Slowly
Also Called Troches or Pastilles
Term
Suppositories
Definition
insertion into cavities
Vaginal called inserts
Effect local or systemic
Term
Powders
Definition
finely ground mixtures of dry drugs
can be mixed with water to use in wet state
Term
Granules
Definition
Powders ground into course, irregular pieces
Carbon Dioxide can be added to make them effervescent
Term
vehicle
Definition
Fluid Medium
Water, Alcohol or Mineral Oil
Term
Solutions
Definition
Homogeneous (evenly distributed)
mixtures of one or more dissolved meds (Solute) in a liquid vehicle (solvent)
Term
Douches
Definition
directed into a body cavity to remove debris or disinfect
Term
Irrigations
Definition
used to wash eyes, the urinary bladder, or open wounds.
larger volumes and area than douches
Term
Enemas
Definition
introduced into the rectum to empty the bowel or treat disease
Term
Gargles
Definition
solutions that treat diseases of the throat; not swallowed
Term
washes
Definition
used to cleanse or bathe a body part, such as eyes or mouth; not swallowed
Example: Scope, Listerine
Term
Sprays
Definition
solutions delivered as a mist against the mucous membranes of the nose and throat
Example: Afrin, Neo-Synephrine
Term
Injection
Definition
sterile drug solution introduced beneath the skin, into the muscle, or into the bloodstream.
Example: D5W
Term
Syrups
Definition
Thick aqueous solution. Mixture of sugar and drug. Used in Peds.
Example: Robitussin, Triaminic
Term
Mucilages
Definition
thick, adhesive liquids containing pulpy components of vegetable matter
Example: Metamucil
Term
Elixer
Definition
Hydro-alcoholic liquid sweetened, stable, and easy to prep.
Alcohol usually 3-25%
Example: Donnatal, digoxin, phenobarbital
Term
Tinctures
Definition
Hydro-alcoholic solution prepared from vegetables, animal or chemical materials having higher alcohol content than elixers
Example: tincture of Opium, Tincture of Iodine
Term
Alcoholic Solutions
Definition
Contain no water
Drug dissolved directly in ethyl alcohol
Example: Collodion
Term
Emulsions
Definition
mixture of two liquids that normally do not mix. Liquid broken into smaller parts is internal phase, the other is called the external or continuous phase. A emulsifying agent is used.
Term
Emulsifying Agent
Definition
Used in Emulsions the molecule has a head that is water loving and a lipid loving tail. This keeps the oil and water together.
Term
Suspensions
Definition
mixtures of fine particles of insoluble solid (Internal or dispersed phase)distributed though a gas, liquid, or solid (dispersion or external phase)
Always attach a "Shake Well" sticker
Term
Injectable Suspensions
Definition
IM or SQ injections
depot therapy (Time release)
Term
Lotions
Definition
external use
cool,soothe, dry, or protect skin.
Example: Calamine Lotion
Term
Ointments
Definition
semi-solid
should have a "for external use only" sticker
topical application or eye
Term
Creams
Definition
semisolid
external application water-in-oil or oil-in-water emulsions
"for external use only" sticker
Term
Pastes
Definition
ointment-like
stiffer, less greasy, and water based than ointments
"for external use only" sticker
Term
Gels
Definition
Two phase system. Solid internal phase diffused throughout a viscous liquid phase.
"For external use only"
Example: K-Y jelly, xylocaine viscous
Term
Inhalers
Definition
Solutions or suspensions of solid or liquid particles in gas or air.
"Shake well before use" label
Example: Ventolin, Azmacort
Term
Aerosols
Definition
suspensions of very fine liquid or solid drug particles in a gas propellant, packaged under pressure
3 Parts: 1.Concentrate, 2.container, 3.propellant
rapid onset external or internal
hard to reach areas or abraded areas
Example: Bactine, Tinactin, ProctoForm-HC
Term
Metered-dose Inhaler (MDI)
Definition
used in inhalation therapy for potent meds
Accurate, fixed amount of drug is delivered with a single depression of the actuator
Examples: Advair, Aerobid, Ventolin
Term
Vial
Definition
2ml to 50ml
Single Dose, or multi dose
Some come as powder that need to be reconstituted
Term
Ampule
Definition
Self contained glass containers
Neck is broken open to draw out sterile liquid with a filtered straw or needle
Term
Oral Route
Definition
through the mouth and swallowed
Abbreviated PO
Term
Sublingual and Buccal Route
Definition
administered into the mouth. Sublingual is placed under the tongue, Buccal is placed inside the cheek. Abbreviation for sublingual is SL. Both routes provide rapid onset of action. Buccal is slower.
Term
Parenteral
Definition
delivery of meds via a needle into the skin, SubQ, Muscles, or Veins
Term
IV
Definition
Intravenous route. through a needle into the vein
Rapid reaction. Must be Sterile and free of particles
Term
Bolus
Definition
IV meds pushed quickly over a small amount if time (IV PUSH)
Term
IV piggy back (IVPB)
Definition
Drug infused into a vein over hours or days by constant infusion or drip.
Term
Intramuscular Injection (IM)
Definition
direct injection of meds into a muscle
Common sites: upper arm, thigh, buttock
More rapid than oral
Term
Subcutaneous (SC, subQ, or SQ)
Definition
Drug is injected under the skin in fatty tissue not muscle
absorbed more slowly than IV or IM.
Term
Intradermal (ID)
Definition
into the top layer of skin
Term
Intraarterial (IA)
Definition
into an artery
Term
Intraarticular
Definition
into a joint
Term
Intracardiac (IC)
Definition
into the heart
Term
Intraperitoneal
Definition
into the abdominal cavity
Term
intraplural
Definition
into the sac surrounding the lung
Term
Intraventricular
Definition
into the cavities of the brain
Term
Intrathecal
Definition
into the space around the spinal cord
Term
Intravaginal
Definition
into the vagina
Term
Intraocular
Definition
into the eye
Term
Topical
Definition
application of drug to the surface of the skin or mucous membrane
Term
Transdermal
Definition
through the skin delivering the drug systemically usually through a patch
Term
Rectal
Definition
abbreviated PR
useful for children or if oral route is unavailable.
Local or systemic effect
solids, solutions, suspensions, or foams
Term
Vaginal Route
Definition
drug inserted into the vagina
local or systemic effects
Suppository, tablet, cream, ointment, gel and soltions
Term
Otic Route
Definition
meds into the ear canal
solutions or suspensions
Abbreviated AD right ear, AS left ear, AU both ears
Term
Ophthalmic Route
Definition
into the eye
Abbreviated OD Right eye, OS left Eye, or OU both eyes. Solutions most common,
Term
Nasal Route
Definition
dugs placed into the nostrils
Term
Inhalation
Definition
meds enter though mouth into the lungs
Rapid onset
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