• Class I
• Enveloped
• Causes dermatic pustules (pox)
• smallpox, cowpox, molluscum contagiosum

• NE Africa 10,000 years ago
• Egyptian, Green Roman empires
• Middle America: 1519: Cortez
• North America: 1633: Plymouth, MA
• Eradicated in 1979

• Humans are only host
• Transmission by inhalation of respiratory droplets

• Fever and malaise
• Rash from head downwards:
• macule, papule, vesicle, pustule (indented), scab or crust, scar

• Isolation
• Post-exposure vaccine
• No FDA approved drugs (some use Cidofovir)
• Passive Ig
• Supportive care

• Dryvax
• Live vaccina cirus (cowpox)
• Stab skin multiple times with bifurcated needle
• Reaction should occur
• 95% effective
• American vaccinations stopped in 1972

• Genus Molluscipoxvirus
• Physical Contact transmission
• Prevalent, 4 serotypes
• children get it from sports or physical contact on face trunk and limbs (MCV 1) 
• adults get it through sex (MCV2)

• Highly contagious but very minor
• Lance, Retin-A, duct tape, cotton ball/vinegar, commercial wart remover, liquid nitrogen, pulsed dye laser, cantharidin, glutaraldehyde

• Self resolving with time
• avoid physical contact, pools

• Class I
• Nonenveloped icosahedral
• Two families infecting humans
• Papillomaviridae (100+ Strains of HPV)
• Polyomaviridae ( 4 strains; BK and JC)

• Direct, indirect, autoinnoculation transmission
• Treatment same as molluscum contag. 

• common ( high-contact areas)
• Filiform (eyelid, armpit, neck)
• Genital
• Flat (face, hand, wrist)
• Plantar (foot)

• HPV-16
• HPV-18
• Potentially HPV-3, -6, -11

• Same as Molluscum contg.
• Condoms
• Vaccine (Gardasil)
• subunit vaccine (capsomers)
• 3-doses, adolescent years
• Papnicolauo (Pap) smear for cervical cancer detection in women

• strict hepatitis must be caused by a viral infection
• Liver inflammation
• Hepatocytes destroyed
• Infiltration and activity of immune system
• liver swells-dysfunctional 
•  Jaundice
• Yellowing of skin, eyes
• Bilirubin backs up in tissues

• Picornaviridae, Class IV
• Stranded RNA (positive sense)

• Hepadnaviridae, Class VII
• Double stranded DNA that replicates through an RNA intermediate    

• Flaviviridae, Class IV

• Single stranded RNA (positive sense)

Hepatitis D ( δ agent)

• Satellite nucleic acid, Class V

• Single Stranded RNA (negative sense) naked rouge RNA 

• Caliciviridae, Class IV

• Single Stranded RNA (positive sense)

• A- fecal oral; food, water
• B- blood; sex; congenital (passed from mother to baby in uterus)
• C- blood; congenital
• D- With Hep B
• E- fecal oral; food, water

• Liver inflammation
• Fever
• GI upset
• Rash
• Arthritis like symptoms
• can masquerade as other things

• None
• Hep A (lots of fluids) 
• If u get rid of Hep B you get rid of Hep D hence why there is no agent for Hep D. 

• B- IFN; entecavir, lamivudine
• C- IFN; ribavirin, simeprevir, sofosbuvir

• produced by leukocytes and fibroblasts
• antiviral and anticancer
• IFN in heptatides
• pegylated
• recombinant
• Give IFN in pegylated form- mix IFN with a chemical (propylene glycol) which acts like a time release capsule
• IFN is genetically engineered so its recombinant and slightly different than what is in the human body

Hep A

• Havris, Vaqtar (inactivated, 2-dose)

• Engerix, Recombivax, and H-B Vax II ( all Hepatitis B surface Antigen, 3-dose); heptavax (plasma, discontinued)