Term
Hydroxychloroquine
Use
Mechanism
Adverse Effects
Contra
Special |
|
Definition
Mild RA/SLE
Alkalinize Lysosome/Vesicle
Impairs Ag processing/cytokine prod.
GI upset
skin rxns (mild)
AGEP-Acute Gen. Exanthematous Pustulosis
Retinopathy
Pre-existing ocular disease
Min effect on done destruction-weak drug |
|
|
Term
Leflunomide
Use
Mechanism
Adverse Effects
Contra
Special |
|
Definition
RA
Prodrug->M1
Inhibit de novo pyrimadine synth.
Arrest in G1
GI
Myelosuppression
Alopecia
Hepatotoxicity
Teratogenesis
Pregnancy/breastfeeding
Hepatic disease
CYP inhibitor
Fast acting (4 wks)
long t1/2 (2 years until cleared) |
|
|
Term
TNF-alpha inhibitors
Use
Mechanism
Adverse Effects
Interactions
Special |
|
Definition
RA
Autoimmun/inflamm disease
Block TNF-alpha from getting to receptor
Infection risk
Hypersensitivity
autoantibody formation
malignancy
cytopenia
neurologic disorders
Not w/anakinra or abatacept
Dont combine 2 TNF-a inhib.
Fast onset 1 day
MTX synergism |
|
|
Term
Anakinra
Use
Mechanism
Adverse Effects
Interactions
Special |
|
Definition
RA
IL-1R antagonist
Immunosuppression
Dont combo w/ TNF-a inhib.
Ineffective alone-use in combo |
|
|
Term
Abatacept
Use
Mechanism
Adverse Effects
Interactions
Special |
|
Definition
RA
CTLA4+IgG
stops costim signal of B7 from APC to T cell
Immunosuppression
Worsen COPD
Dont combo w/ TNF-a inhib.
Ineffective alone-use in combo |
|
|
Term
Rituximab
Use
Mechanism
Adverse Effects
Contra
Special |
|
Definition
B cell lymphomas
leukemias
RA (w/ MTX)
mouse/human IgG to CD20
inhib B cell activation
B cell depletion for 6-9 months
Cytopenia
Infection risk up
Mucocutaneous rxns
Cardiac dysfunction
Hypersensitivity
additive hypotension |
|
|
Term
Sulfasalazine
Use
Mechanism
Adverse Effects |
|
Definition
IBD
RA
AICAR build up
Metabolites
1. Antibacterial
2. Inhib. prostaglandin and LTriene synthesis |
|
|
Term
|
Definition
TNF-alpha inhibitor
Human IgG to TNF-a |
|
|
Term
|
Definition
TNF-alpha inhibitor
Human IgG + TNF receptor |
|
|
Term
|
Definition
TNF-alpha inhibitor
Human monoclonal Ab to TNF-a |
|
|
Term
Certolizumab
Class
Structure |
|
Definition
TNF-alpha inhibitor
Fab of Human Ab to TNF-a |
|
|
Term
Infliximab
Class
Structure
Adverse Effects |
|
Definition
TNF-alpha inhibitor
Human-mouse Ab to TNF-a
Worse side effects
Infusion rxn
Hepatic failure |
|
|
