Term
| What protein is involved in transporting an endocytosed vesicle from the plasma membrane to the endosome? |
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Definition
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Term
| What molecule targets proteins in the endoplasmic reticulum for lysosomes? |
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Definition
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Term
| What drugs act on microtubules? |
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Definition
| Paclitaxel, Grizeofulvan, Mebendazole, Vincristine, Colchecine |
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Term
| What findings are a/w Ehlers-Danlos syndrome |
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Definition
Defect in type III collagen;
Hyperextensible skin, tendency to bleed (easy brusing), hypermobile joints |
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Term
Which arachidonic acid product causes the following affect:
Increased bronchial tone |
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Definition
Leukotrienes (LTC4 and LTD4)
Thromboxane (TXA2) |
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Term
Which arachidonic acid product causes the following affect:
Decreased bronchial tone |
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Definition
Prostaglandins (PGE2, PGF2a)
Prostacyclins (PGI2) |
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Term
Which arachidonic acid product causes the following affect:
Increased platelet aggregation |
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Definition
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Term
Which arachidonic acid product causes the following affect:
Decreased platelet aggregation |
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Definition
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Term
Which arachidonic acid product causes the following affect:
Increased uterine tone |
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Definition
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Term
Which arachidonic acid product causes the following affect:
Decreased uterine tone |
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Definition
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Term
Which arachidonic acid product causes the following affect:
Increased vascular tone |
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Definition
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Term
Which arachidonic acid product causes the following affect:
Decreased vascular tone |
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Definition
Prostacyclins
Prostaglandins |
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Term
| What are the two most abundant substances in the plasma membrane |
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Definition
| Cholesterol, phospholipids |
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Term
| What provides the structural framework for DNA and the nuclear envelope |
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Definition
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Term
| What drugs act on the arachidonic pathway? |
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Definition
| Corticosteroids, Zileuton,, Zafirlukast, COX inhibitors, NSAIDs, acetominophen |
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Term
| Describe the process of leukocyte extravasation |
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Definition
Rolling mediated by selectins
Tight binding mediated by integrins
Diapedesis mediated by PECAM
Migration mediated by chemotactic factors |
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Term
| How are molecules transported into the nucleus? |
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Definition
| Nuclear localization signals |
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Term
| What histologic features are seen in apoptotic liver cells? |
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Definition
| cellular shrinkage, nuclear shrinkage and basophilia, membrane blebbing, pyknotic nuclear fragmentation, nuclear fading, formation of apoptotic bodies |
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Term
| What are the signaling pathway effects of Gq? |
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Definition
| Activates phospholipase C--> generates IP3--> IP3 increase intracellular Ca--> Phopholipase C makes DAG--> DAG activates protein kinase C |
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Term
| WHat are the signaling pathway effects of Gs? |
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Definition
| Stimulates adenylyl cyclase to use ATP to make cAMP-->activates Protein kinase A |
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