Term
| Patients of what disease are often employed at circuses as "India rubber men"? |
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Definition
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Term
| A connective tissue disorder that causes bleeding due to increased fragility of subcutaneous vessels. The patients joints are hyperextensible. |
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Definition
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Term
| Is Ehler's-Danlos Syndrome acquired or inherited? |
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Definition
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Term
| An inherited disorder characterized by serious bleeding secondary to abnormal elastic fibers in the skin and the media of the arteries. |
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Definition
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Term
| A connective tissue disorder with many other physical manifestations. Causes mild bleeding tendencies. Abraham Lincoln may have had this disorder. |
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Definition
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Term
| "devil's pinches"; an acquired disorder of unknown cause; usually causing bruising in females |
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Definition
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Term
| 3 inherited bleeding disorders due to problems of the subendothelium |
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Definition
| Ehler's-Danlos Syndrome, Pseudoxanthoma elasticum, Marfan's syndrome |
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Term
| Bruises on hands and forearms, usually seen in older patients; caused by the loss of dermal and vascular support. |
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Definition
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Term
| Vitamin C deficiency resulting in defective collagen and otehr supportive structures. Patients may have pale skin, loss of teeth, and sunken eyes. |
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Definition
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Term
| Three acquired bleeding disorders due to problems of the subendothelium |
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Definition
| Purpura simplex, senile purpura, scurvy |
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Term
| Osler-Weber-Rendu syndrome is another name for what inherited disorder? |
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Definition
| Hereditary Hemorrhagic Telangiectasia |
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Term
| An autosomal dominant disorder characterized by cutaneous lesions called A-V malformations, which hold blood and appear as red-colored spots. |
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Definition
| Hereditary Hemorrhagic Telangiectasia |
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Term
| Why is Hereditary Hemorrhagic Telangiectasia more common than most other vascular diseases? |
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Definition
| Because it's autosomal dominant |
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Term
| allergic purpura, hepatitis B- associated vaculitis, various infections and reactions to drugs; all these inflammatory disorders are acquired disorders of what part of the vascular system? |
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Definition
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Term
| The deficiency of the Glycoprotein IIb/IIIa complex on the platelet surface. Abnormal bleeding time and platelet aggregation tests. Autosomal recessive disease |
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Definition
| Glansman's Thrombasthenia |
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Term
| The deficiency of the Glycoprotein Ib receptor. Autosomal recessive. |
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Definition
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Term
| Bernard Soulier patients are clinically identical to patients with what other disease? |
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Definition
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Term
| Three diseases that produce substances which coat the platelet receptors? |
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Definition
| uremia, multiple myeloma, anti-platelet antibodies |
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Term
| The deficiency of the von Willebrand's Factor molecule which binds the platelet to the collagen |
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Definition
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Term
| Which is more common, Bernard Soulier Disease or Von Willebrand's Disease? |
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Definition
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Term
| DDAVP is used to treat what disease? |
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Definition
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Term
| How is von Willebrand's disease inherited? |
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Definition
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Term
| deficiency of Factor VIII due to a defective gene on the X chromosome |
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Definition
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Term
| Which disease is characterized by bleeding into the joints? |
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Definition
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Term
| Which disease is characterized by bleeding from the gums, nose bleeds, and heavy menstrual bleeding in females? |
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Definition
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Term
| epistaxis is bleeding from what body part? |
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Definition
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Term
| A bleeding disease that has a normal bleeding time, normal aggregation studies, prolonged APTT and decreased factor VIII level |
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Definition
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Term
| People with hemophilia B have a decrease in what factor? |
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Definition
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Term
| which version of hemophilia is treated by using plasma replacement or commercial Factor IX replacement? |
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Definition
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Term
| name five factor deficiencies that are autosomal recessive and extremely rare. |
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Definition
| Factor II, Factor V, Factor VII, Factor X, Factor XIII |
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Term
| Hemophilia C is a deficiency of what factor? |
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Definition
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Term
| Autosomal dominant factor deficiency with over 40 abnormal variants with a spectrum of clinical expression. |
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Definition
| Factor I (fibrinogen) deficiency |
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Term
| How is Hemophilia C inherited? |
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Definition
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Term
| A phenomenon most commonly seen in the elderly and in post partum females; similar to Hemophelia A but much more difficult to treat. |
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Definition
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Term
| An antibody, usually IgG, to the phospholipid platelet membrane. Can prolong both PT and APTT, but does not cause bleeding. |
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Definition
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Term
| Vitamin K deficiency causes functional deficiency of what four factors? |
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Definition
| Factors II, VII, IX and X |
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Term
| If a woman poisons her husband with rat poison, he will die of what vitamin deficiency..? |
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Definition
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Term
| In what organ are factors I, II, V, VII, IX and X produced? |
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Definition
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Term
|
Definition
| disseminated intravascular coagulation |
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Term
| In primary fibrinolysis, are d-dimers produced? |
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Definition
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Term
| A very common chronic condition of arterial damage and the formation of atherosclerotic plaque. The acute phase of the blockage is driven by a platelet clot at the injury site which blocks the blood supply. |
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Definition
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Term
| an acquired disease of endothelial cells resulting in the loss of prostacyclin function and the release of vWF. |
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Definition
| Thrombotic Thrombocytopenia Purpura (TTP) |
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Term
| oral anticoagulants which inhibit Vitamin K |
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Definition
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Term
| an anti-platelet drug that blocks cyclo-oxygenase |
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Definition
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Term
| an anti-platelet drug that inhibits platelet adhesion |
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Definition
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Term
| what test is used to monitor coumadin or warfarin therapy, and what is the desired result? |
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Definition
| Prothrombin time/ the goal is to get a prolongation of PT of 2x normal |
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Term
| an anticoagulant that binds and activates Antithrombin III, which inhibits the activated serine proteases. |
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Definition
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Term
| what test is used to monitor patients on heparin therapy, and what is the desired result? |
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Definition
| APTT, the goal is to be prolonged 2x normal |
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Term
| A clot busting drug that was once produced from horse urine but is now produced from human renal cells in tissue culture |
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Definition
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Term
| name two anticoagulant drugs |
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Definition
|
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Term
| name two anti-platelet drugs |
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Definition
|
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Term
| name three clot busting drugs |
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Definition
| urokinase, streptokinase, tissue plasminogen activator |
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Term
| the latest and most expensive clot busting drug. Made with new recombinant DNA technology |
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Definition
| tissue plasminogen activator |
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Term
| a product of beta hemolytic streptococci; still a widely used clot busting drug |
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Definition
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Term
| name two general categories of disorders of the hemostatic system |
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Definition
| bleeding disorders and clotting disorders |
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Term
| another word for clotting |
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Definition
|
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Term
| two subsets of antiphospholipid antibody syndrome |
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Definition
| Lupus anticoagulant and Anti-cardiolipin antibody |
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Term
| an autosomal dominant disorder that can lead to both arterial and venous thrombosis; characterized by spontaneous platelet aggregation in vitro |
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Definition
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Term
| A mutated form of Factor V that leads to Activated Protein C resistance |
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Definition
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Term
| what is the most common inherited form of hypercoagulability? |
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Definition
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Term
| what inherited disorder is present in 3-15% of caucasians of northern european origin, but rare in persons of african or asian ancestry? |
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Definition
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Term
| The screening test called Activated Protein C Resistance Test is used to test for what disorder? |
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Definition
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Term
| A mutated prothrombin gene seen in 2-3% of general population and 5-18% of people with family history of deep vein thrombosis |
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Definition
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Term
| anti-clotting drugs that inhibit ADP receptors |
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Definition
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Term
| How is heparin therapy administered? |
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Definition
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Term
| an overdose of warfarin is counteracted with what? |
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Definition
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|
Term
| what drug is used to counteract a heparin overdose? |
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Definition
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Term
| vasoconstriction and formation of platelet plug are what phase of hemostasis? |
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Definition
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Term
| fibrin clot formation and fibrinolysis are in what phase of hemostasis? |
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Definition
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|
Term
| two types of platelet function tests |
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Definition
| platelet aggregation and clot retraction |
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Term
| what does PRP stand for, and how do you get it? |
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Definition
| Platelet rich plasma; you get it by centrifuging slowly |
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Term
| what aggregating agents are used in the platelet aggregation test? |
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Definition
| ristocetin, ADP, collagen, and arachidonic acid |
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Term
| In a platelet aggregation test on a patient with von willebrand's disease, which aggregating agent will cause incomplete or no aggregation? |
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Definition
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Term
| In a mixing study, if the pooled normal plasma does not correct the result, what is indicated? |
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Definition
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|
Term
| in the mixing study test, if the addition of pooled normal plasma corrects the result, what is indicated? |
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Definition
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|
Term
| what factor deficiency is associated with umbilical stump bleeding? |
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Definition
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|
Term
| what factor deficiency is the 5 M Urea Test used to test for? |
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Definition
|
|
Term
| what are lupus anticoagulants directed against? |
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Definition
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Term
| What two tests are good to use to test for lupus anticoagulant? |
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Definition
| Kaolin clot time and platelet neutralization |
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Term
| Fletcher factor is another name for what? |
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Definition
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Term
| If a prolonged APTT is corrected by incubating the serum for 15 minutes instead of 5, what is indicated? |
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Definition
| fletcher factor deficiency |
|
|
Term
| what does DRVVT stand for, and what is it used for? |
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Definition
| Dilute Russel's Viper Venom Test, used to test for Lupus Anticoagulant |
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|
Term
| what test can be used to rule out heparin contamination? |
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Definition
|
|
Term
| What is the cofactor to Protein C? |
|
Definition
|
|
Term
| what activates Protein C? |
|
Definition
| Thrombin and thrombomodulin |
|
|
Term
| do immunologic assays measure function? |
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Definition
|
|
Term
| name four things that could cause acquired antithrombin III deficiency? |
|
Definition
| DIC, liver diease, sepsis, trauma |
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Term
| in the antithrombin III chromogenic assay, what is the relationship between the amount of color and the amount of patient antithrombin III? |
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Definition
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|
Term
| In the Activated Protein C resistance test, what result would indicate the presence of Factor V Leiden? |
|
Definition
|
|
Term
| what is a quantitative but not functional test to check for von willebrand factor antigen? |
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Definition
|
|
Term
| How is prothrombin gene mutation detected? |
|
Definition
|
|
Term
| what is a functional assay to test for von willebrand disease? |
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Definition
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