Term
| Purpose of Inflammation & Immunity |
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Definition
| To meet human need for protection by neutralizing, eliminating, or destroying organisms that invade the internal environment. |
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Term
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Definition
Unique universal product code for each person.
Present on surface of nearly ALL body cells.
Act as antigens only if enter another person's body. |
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Term
| Organization of the Immune System (Bone Marrow) |
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Definition
Source of all blood cells, including immune system cells.
Produces stem cells. |
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Term
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Definition
Immature undifferentiated cells.
Pluripotent (each cell has more than 1 potential outcome).
Pathway depends on body needs & presence of growth factors. |
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Term
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Definition
| Protect body from effects of invasion by organisms. (Knights & Soldiers protecting the castle) |
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Term
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Definition
1. Recognition of self vs non-self
2. Destruction of foreign invaders, cellular debris, & unhealthy or abnormal self cells.
3. Production of antibodies directed against invaders
4. Complement activation.
5. Production of cytokines that stimulate increased formation of leukocytes in bone marrow & increase specific leukocyte activity |
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Term
| Leukocytes involved in inflammation |
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Definition
Neutrophil
Macrophage
Monocyte
Eosinophil
Basophil |
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Term
| Neutrophil Inflammation Fx |
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Definition
| Nonspecific ingestion & phagocytosis of microorganisms & foreign protein |
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Term
| Macrophage Inflammation Fx |
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Definition
| Nonspecific recognition of foreign proteins & microorganisms; ingestion & phagocytosis |
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Term
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Definition
| Destruction of bacteria & cellular debris; matures into macrophage. |
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Term
| Eosinophil Inflammation Fx |
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Definition
| Weak phagocytic action; releases vasoactive amines during allergic reactions. |
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Term
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Definition
| Releases histamine & heparin in areas of tissue damage. |
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Term
| Leukocytes involved in Antibody-Mediated Immunity |
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Definition
B-lymphocyte
Plasma cell
Memory cell |
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Term
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Definition
| Becomes sensitized to foreign cells & proteins. |
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Term
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Definition
| Secretes immunoglobulins in response to the presence of a specific antigen. |
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Term
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Definition
| Secretes immunoglobulins in response to the presence of a specific antigen. |
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Term
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Definition
| Remains sensitized to a specific antigen & can secrete increased amounts of immunoglobulins specific to the antigen on re-exposure. |
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Term
| Lymphocytes Involved in Cell-Mediated Immunity |
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Definition
T-lymphocyte helper/inducer T-cell
Cytotoxic/cytologic T-cell
Natural killer cell |
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Term
| T-lymphocyte helper/inducer T-cell Immunity Fx |
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Definition
| Enhances immune activity through secretion of various factors, cytokines, & lymphokines. |
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Term
| Cytotoxic/cytolytic T-cell Immunity Fx |
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Definition
| Selectively attacks & destroys non-self cells, including virally infected cells, grafts, & transplanted organs. |
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Term
| Natural Killer Cell Immunity Fx |
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Definition
| Nonselectively attacks non-self cells, especially body cells that have undergone mutation & become malignant; also attacks grafts & transplanted organs. |
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Term
| Difference b/t Inflammation & Immunity |
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Definition
1. Provides immediate b/ short-term against injury or invading organism. It doesn't provide true immunity on repeated exposure to the same organisms.
2. Inflammation is a NONSPECIFIC body defense to invasion or injury & can be statred quickly by almost any event, regardless of where it occurs or what it causes. |
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