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Disease & Infections
Transmission, Incubation, etc.
42
Immunology
Undergraduate 3
10/05/2014

Additional Immunology Flashcards

 


 

Cards

Term
Define Epidemiology
Definition
The study of the frequency, distribution, and determinants in a population.
- and the application of this study to the control of health problems
Term
Define Determinant
Definition
A factor that, when altered, changes the frequency or characteristics of a disease
(aka: exposure, risk factor, independent variable, explanatory variables, etc.)
Term
Define Outcome of Interest
Definition
The response to the change in determinant
- "the dependent variable"
(e.g. disease, health, productivity, immune status)
Term
Is the Outcome of Interest a dependent or independent variable?
Definition
Dependent
Term
Is the Determinant a dependent or independent variable?
Definition
Independent Variable
Term
What were two methods of Primary Intervention Prevention put in place to reduce the BSE epidemic?
Definition
- banning Meat & Bone Meal (MBM) being fed to ruminants (1997)
- Removing Specified Risk Material from circulation, possibly preventing Variable Creutzfeldt-Jakob Disease (vCJD)
Term
Define BSE
Definition
Bovine Spongiform Ecephalopathy
- Mad Cow Disease
Term
What composes the Epidemiological Triad?
Definition
Host(s), Agent(s), Environment(s)
Term
What dictates the impact of infection at both the individual and population levels?
Definition
The interactions b/w the host, agent, and environment
Term
What are some factors that differ b/w hosts?
Definition
Age, gender, breed & species (phenotypic and genotypic), physiologic state
Term
What are some factors that differ b/w environments?
Definition
Air, water, soil, rainfall, temperature
Term
What are some factors that differ b/w agents?
Definition
Virulence, antimicrobial resistance, etc.
Term
What are some infectious agents?
Definition
Bacteria, parasites, viruses, fungi, prions
Term
What are the two transmission types of infectious diseases?
Definition
Horizontal (direct or indirect)

Vertical (in utero, in ovo, via milk)
Term
What are the routes of horizontal transmission?
Definition
Ingestion, Aerial (droplet, airborne), contact ((in)direct), Iatrogenic, Sexual, Vector
Term
What is a vector?
Definition
An insect or any living carrier that transports an infectious agent from an infected individual (or its wastes) to a susceptible individual or its food, or immediate surroundings
Term
Define Zoonosis
Definition
Any disease that is transmissible BETWEEN animals and humans

- NOT just from animals to humans
Term
Define Infected
Definition
Host is invaded by microorganisms, the organisms multiply, and the host's immune system responds
Term
Define Diseased
Definition
An infection causes clinical signs/symptoms
Term
T or F: All infections cause disease
Definition
False
e.g. HIV doesn't necessarily cause AIDS
Term
Define Sub-clinical Infection
Definition
Agent infects the host, stimulates immune system, but does not cause overt disease
Term
Define Colonized
Definition
Infectious agent establishes itself in the host, but the immune system is NOT stimulated to respond, thus the host is not considered "infected" (e.g. E. coli in our LI)
Term
T or F: host appears sick in Sub-clinical disease, but not in colonized disease
Definition
False: Neither of these diseases have hosts who display signs
Term
T or F: Sub-clinically and colonized diseased patients cannot spread the infectious agent
Definition
False, they both can (e.g. fecal contamination, bodily fluids, etc)
Term
What are the stages of disease development? (1)
Definition
1. Susceptibility
2. Pre-symptomatic Disease
3. Clinical Disease
4. Disability or Recovery
Term
Define Incubation Period
Definition
The time b/w exposure to a sufficient cause, and the evidence of clinical disease
Term
Define Latent Period
Definition
The time b/w exposure to a sufficient cause, and the detection of the pathologic process
Term
What are the stages of disease development? (2)
Definition
1. Exposure to sufficient cause
2. Pathologic Process detectable
3. Clinical Disease Evident
4. Outcome (survival or productivity)
Term
Define Sporadic
Definition
Occurs occasionally in a population (i.e. the prevalence is zero)
Term
Define Endemic
Definition
Occurs at an expected level in a population within a given geographic area, at an expected level
Term
Define Epidemic
Definition
Disease occurs as new cases in a given population, during a given period, at a rate that substantially exceeds what is expected.
Term
Define Pandemic
Definition
A disease that is widespread over a large area - a worldwide epidemic. Crosses international borders
Term
What are the different kinds of immunity?
Definition
Innate immunity (non-antigen specific i.e.skin, white blood cells, stomach acid)

Acquired Immunity (passive & active)

Herd Immunity (community immunity)
Term
Define Herd Immunity
Definition
Resistance of a group to a disease
- associated with a large proportion of non-susceptibles
Term
As the number of non-susceptible indv. increase, the chance of an infectious indv. contacting a susceptible will...
Definition
decrease
Term
As the number of non-susceptibles increase, the overall herd immunity...
Definition
increases
Term
With herd immunity, the entire population is said to be _________, while an individual may be _________. [protected/unprotected]
Definition
protected
unprotected
Term
What are the qualifiers of herd immunity?
Definition
1. Infectious agent needs to be restricted to ONE host species
2. Transmission needs to be relatively direct
3. Infection must induce full immunity
4. Individuals need to be randomly mixed (technically not realistic i.e. family members, classmates, friends, etc)
Term
What are the levels of prevention?
Definition
Primary: Prevention (reducing exposure, decreasing susceptibility, increasing host resistance) e.g. nutrition, vaccines, prophylaxis

Secondary: early detection/screening

Tertiary: Psychosocial, medical, occupational, and physical rehabilitation
Term
At which stage of disease (2) do we administer primary intervention?
Definition
Before exposure
Term
At which stage of disease (2) do we administer secondary intervention?
Definition
B/w when the pathological process is detectable and evidence of clinical disease arises
Term
At which stage of disease (2) do we administer tertiary intervention?
Definition
After there is evidence of clinical disease
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