Term
| Diphenhydramine - Trade Name |
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Definition
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Term
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Definition
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Term
| Diphenhydramine - description |
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Definition
- blocks H1 histamine receptor sites
- indicated when excess histamine present (ex. acute urticaria)
- adjunctive thereapy (ex. use w/ epi) in treatment of anaphylactic shock
- treatment of certain extrapyrimidal (dystonic) reaction and for relief of upper respiratory and inus symptoms associated with allergic reactions
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Term
| Diphenhydramine - Onset and Duration |
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Definition
Onset: max effects 1-3 hours
Duration: 6-12 hours |
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Term
| Diphenhydramine - indications |
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Definition
- moderate to severe allergic reactions (after epi)
- anaphylaxis
- acute extrapyrimidal (dystonic) reactions
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Term
| Diphenhydramine - Contraindications |
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Definition
- pt's taking MAOI's
- hypersensitivity
- narrow-angle glaucoma (relative)
- newborns and nursing mothers
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Term
| Diphenhydramine - Adverse reactions |
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Definition
- dose related drowsiness
- disturbed coordination
- thickening of bronchial secretions
- dry mouth and throat
- palpitations
- tachycardia
- bradycardia
- hypotension
- paradoxical excitation in children
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Term
| Diphenhydramine - drug interactions |
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Definition
- CNS depressants - may increase depressant effects
- MAOI's - may prolong and intensify anticholinergic effects
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Term
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Definition
| parenteral 10 and 50 mg/ml vials, prefilled syringe |
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Term
Diphenhydramine - Dosage and Administration
Adult |
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Definition
| 10-50mg IM / slow IV every 6-8 hours (max. 400 mg/day) |
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Term
Diphenhydramine - Dosage and Administration
Pediatric |
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Definition
*over 10kg
1.25mg/kg/dose q 6hr (max 300mg/day) |
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Term
| Diphenhydramine - Special Considerations |
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Definition
- pregnancy category: C
- use cautiously in pt's w/ CNS depression or lower respiratory disease (ex. asthma)
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