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diabetes, endocrine
5
48
Pharmacology
Undergraduate 2
02/12/2015

Additional Pharmacology Flashcards

 


 

Cards

Term
vasopressin uses
Definition
Diabetes insipidus, vasodilatory shock,
gi bleeding
Term
somatropin uses
Definition
Growth hormone deficiency
HIV wasting
Term
octreocide uses
Definition
acromegaly (excess GH)
metastatic carcinoid tumor (controls diarrhea)
VIPoma
Term
desmopressin/ vasopressin adverse effects
Definition
increase BP
fever
vertigo
uterine cramping
nasal irritation
tremor, sweating
Term
somatropin adverse effects
Definition
headache, muscle pain
injection site inflammation
hypo & hyperglycemia
Term
somatropin contraindications
Definition
children w/ closed growth plates,
tumors
acute illnesses
Term
octreocide adverse effects
Definition
fatigue
increase or decrease in blood glucose
dyspnea
joint pain
cardiovascular conduction abnormalities
Term
With ocetreocide the provider may order an _______ prior to use.
Definition
ECG- due to conduction abnormalities
Term
desmopressin- check for history and use caution with what conditions
Definition
seizures, asthma, or cardiovascular disease
Term
desmopressin uses
Definition
Diabetes insipidus, hemophilia
type 1 von Willebrand's disease
Term
vasopressin IV infiltration may lead to ______.
Definition
severe vasoconstriction, tissue necrosis.
Term
what are the three rapid acting insulins?
Definition
lispro, aspart, gluisine
Term
Rapid-acting insulin onset, pk, duration
Definition
15 min, 1-2 hr, 3-5 hr
Term
short acting insulin onset, pk, duration
Definition
30-60 min
2.5 hr
6-10 hr
Term
intermediate-acting (NPH) onset, pk, duration
Definition
1-2 hr
4-8 hr
10-18 hr
Term
which insulin is referred to as a basal insulin
Definition
glargine
Term
vasopressin mimics what hormone?
Definition
ADH
Term
Which type of diabetes does metformin treat?
Definition

type 2

 

Term
what drug is the first-line drug for type 2 diabetes
Definition
metformin
Term
what class is metformin?
Definition
biguanide
Term
metformin works by decreasing glucose production by the ______?
Definition
liver
Term
most common adverse reactions of metformin?
Definition
gastrointestinal (bloating, nausea, cramping, diarrhea)
Term
Mechanism of action: glinide class?
Definition
increase insulin secretion from the pancreas.
Term
Glinides can't be used along with which other diabetic drug class?
Definition
sulfonylureas
(because they have a similar action)
Term
true/false:
glinides must be given with each meal?
Definition
true (they have a short duration)
Term
metformin is contraindicated in patients with what three conditions?
Definition
renal disease, alcoholics, cardiopulmonary disease
Term
adverse effects of glinides?
Definition
hypoglycemia (esp if not taken w/ food)
Term
contraindications of glinides and sulfonylureas?
Definition
hypoglycemia and conditions that predispose pt to hypoglycemia (NPO, advanced age)
Term
glipizide works best given ____ minutes before a meal
Definition
30 minutes
Term
thiazolidinedoines are commonly reffered to as ________?
Definition
glitazones
Term
pioglitazone can be used with insulin? t/f
Definition
true
Term
thiazolidinediones (glitones) mode of action?
Definition
enhance the sensitivity of insulin receptors, stimulate peripheral glucose uptake/storage
Term
thiazolidinediones adverse effects?
Definition
increase risk of heart failure, peripheral edema and weight gain, reduced bone mineral density
Term
Alpha-Glucosidase inhibitor drug
Definition
acarbose
Term
sitagliptin, saxagliptin, linagliptin drug class?
Definition
Dipeptidly Peptidase IV inhibitors
Term
How do DPP-IV inhibitors work?
Definition
delaying the breakdown of incretin hormones
Term
acarbose should be taken when?
Definition
with the first bit of each meal
Term
DPP-IV drug adverse effects?
Definition
upper respiratory infection, headache and diarrhea
Term
Which antidiabetic drug should be discontinued at least 48 hours prior to any radiologic study requiring such contrast media and should be held for at least 48 hours after the procedure?
Definition
metformin
Term
what drug class is pramlintide? how/when is it administered?
Definition
amylin agonist, injectable, taken before major meals
Term
which type of diabetes is amylin agonists (pramlintide) used to treat?
Definition
both 1 and 2.
Term
how does pramlintide work/ mechanism of action?
Definition
slows gastric emptying
suppress glucagon secretion
increase satiety
Term
what class does exenatide belong to?
Definition
incretin mimetics
Term
incretin mimetics mechanism of action?
Definition
stimulates insulin secretion
reduce postprandial glucagon production
slow gastric emptying
increase satiety
Term
glucocorticoid main uses
Definition
anti-inflammatory,
immunosuppressant (lupus, RA, MS, auto-immune flare-up, asthma
Term
Name two glucocorticoids? which one is the preferred oral? which is the most common injectable?
Definition
prednisone
methylprednisone
Term
adverse side effects of glucocorticoids?
Definition
moon face, hunger, weight gain, edema, mood swings, hyperglycemia, psychosis
Term
Glucorticoids cause edema so they should be used with caution in patients with _______?
Definition
heart failure
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