Term
|
Definition
| start conservatively ~0.5 units/kg/day (rang: 0.4-1.0 units/kg/day) |
|
|
Term
| Repeated hypoglycemic events lead to |
|
Definition
| deficient counter-regulatory hormone release; deficient autonomic response (Tachycardia, etc) |
|
|
Term
|
Definition
| estimates how far one unit of insulin will drop the blood glucose |
|
|
Term
| Continuous Subcutaneous Insulin Infusion (CSII) |
|
Definition
| uses rapid acting insulin; uses one injection site for several days; closest match with physiologic needs |
|
|
Term
| Add on therapy to metformin: DDP-4 inhibitor |
|
Definition
| negligible hypoglycemia risk; oral route; no need for titration |
|
|
Term
| Add on therapy to metformin: GLP-1 Receptor Agonist |
|
Definition
| weight reduction; negligible hypoglycemia risk; injectable route; must titrate |
|
|
Term
| Add on therapy to metformin: Sulfonylurea |
|
Definition
| weight gain; increased hypoglycemia risk; oral route; must titrate |
|
|
Term
| Add on therapy to metformin: Pioglitazone |
|
Definition
| weight gain; negligible hypoglycemia risk; oral route; must titrate |
|
|
Term
| add on therapy to metformin: basal insulin |
|
Definition
| weight gain; increase hypoglycemia risk; injectable route; must titrate |
|
|
Term
|
Definition
| monitor patients carefully for pancreatitis after initiation of therapy or dose increases; use cautiously and with appropriate monitoring in patients with a history of pancreatitis |
|
|
Term
|
Definition
| Greater in patients with T2DM than those without diabetes |
|
|
Term
| Diabetes and Fracture Risk |
|
Definition
| Bone density and quality (BMD increased; bone quality reduced); Increased risk of falls (sensory loss due to neuropathy--postural instability |
|
|
Term
|
Definition
| no renal contraindication to metformin; monitor renal function annually |
|
|
Term
| on metformin: eGFR < 60 and > 45 |
|
Definition
| continue use, increase monitoring of renal function (every 3-6 months) |
|
|
Term
| on metformin: eGFR < 45 and > 30 |
|
Definition
| prescribe metformin with caution; use lower dose; closely monitor renal function; do not start new patients on metformin |
|
|
Term
|
Definition
|
|
