Term
| what causes microvascular disease? |
|
Definition
|
|
Term
| chronic kidney disease, foot problems, and eye damage are considered [micro/macro] vascular events? |
|
Definition
|
|
Term
| MI, chest pain, CHD, stroke, and CHF are considered [micro/macro] vascular events? |
|
Definition
|
|
Term
DCCT studied [type 1/type 2] DM
UKPDS studied [type 1/type2] DM |
|
Definition
DCCT - type 1
UKPDS - type 2 |
|
|
Term
|
Definition
| aka. legacy effect; early hyperglycemia causes glycalation of proteins and endothelial dysfunction; this damage persists despite later intensive treatment and is reflected as an elevated risk of microvascular events |
|
|
Term
| AE: increases risk of CV complications and fractures |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| closes K-ATP channels to increase insulin secretion |
|
|
Term
| MOA (3) and AE of GLP-1R agonists |
|
Definition
| MOA: increases insulin secretion, inhibits glucagon secretion, inhibits hepatic GNG, causes satiety; AE: nausea |
|
|
Term
|
Definition
| insulin sensitizer; decreases hepatic GNG |
|
|
Term
|
Definition
|
|
Term
|
Definition
| alpha-glucosidase inhibitors |
|
|
Term
|
Definition
| amylin mimetic; decreases glucagon secretion |
|
|
Term
| short-acting insulins (3) |
|
Definition
| Lispro, Aspart, Regular [FirstAid] |
|
|
Term
|
Definition
|
|
Term
|
Definition
| glargine, detemir [FirstAid] |
|
|
Term
1. short acting insulins are used to control post-prandial plasma glucose or fasting plasma glucose?
2. long acting insulins? |
|
Definition
short acting -> post-prandial
long acting -> fasting |
|
|
Term
|
Definition
|
|
Term
target LDL in presence of CV disease = ?
target LDL in absence of CV disease = ? |
|
Definition
presence: 70mg/dl
absence: 100mg/dl |
|
|
Term
| tx for insulin-sensitive type 2 DM pts with normal BMI and low CV risks |
|
Definition
|
|
Term
|
Definition
| metformin, TZD, or alpha-glucosidase inhibitor |
|
|
Term
|
Definition
| sulfonylurea, meglitinides, DPP-4 inhibitor |
|
|
Term
|
Definition
| insulin, incretin mimetics |
|
|
