Shared Flashcard Set

Details

Diabetes Meds MOAs
Mechanism of Action of Oral Medications
9
Other
Not Applicable
10/04/2012

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Cards

Term
Second Generation Sulfonylureas
Definition
Insulin secretagogues; increase basal and meal-stimulated insulin secretion
Term
Meglitinides/Phenylalanines
Definition
Insulin seretagogues
Term
Biguanides
Definition
Improves insulin sensitivity by reducing insulin resistance: decreases hepatic glucose production, increases skeletal muscle glucose uptake, decreases intestinal absorption of glucose
Term
Thiazolidinediones
Definition
Directly reduces insulin resistance by activating PPAR-gamma nuclear receptors; increases glucose uptake in skeletal muscle and fat cells, lower hepatic glucose output
Term
alpha-glucosidase inhibitors
Definition
inhibit membrane-bound alpha-glucosidase enzymes in small intestine; decrease glucose absorption from intestine, reducing postprandial hyperglycemia
Term
bile acid sequestrant
Definition
lowers LDL cholesterol, lowers A1C by about 0.5%
Term
Bromocriptine
Definition
Acts on CNS to improve insulin resistance and glucose tolerance-- resets neuroendocrine rhythms.
Term
DDP-IV inhibitors
Definition
increases levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) leading to increased insulin secretion, decreased hepatic glucose produciton, and delayed gastric emptying
Term
GLP-1 Agonists
Definition
increases glucose-dependent insulin secretion, decreases glucagon secretion, decreases hepatic glucose production, delays gastric emptying, and increases satiety
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