Dextrose 50% in Water (D50W)

(Dextrose 25% for Pediatrics)

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Classification:         

Hyperglycemic Agent

Action:           

Provides immediate source of glucose that can be rapidly

used for cellular metabolism

Indications:            

Altered level of consciousness due to hypoglycemia

Contraindications: 

Patients without documented hypoglycemia

Adverse Effects:     

Administration:     

    50 ml (25g) IV/IO  May repeat one time.

Pediatrics: 

0-2 years:                

2ml/kg of D25W slow IV/IO at 10 ml/min.  May repeat one time

Onset:    

Duration:                   

Onset:                         30-60 seconds

Duration:     Depends on the degree and cause of

                 hypoglycemia

Precautions:            

Verify hypoglycemia with a blood glucose test.  D50W may increase cerebral ischemia or infarction caused by intracranial hemorrhage or increase cerebral edema in patients with normal or elevated blood glucose levels.

Establish IV in the largest vein possible.  Patients may experience pain, warmth or burning at the IV site and can develop phlebitis, sclerosis or thrombosis of the vein.

Ensure IV patency by aspirating prior to administration and then every 10-15ml during administration. Concentrated dextrose causes tissue necrosis if injected into the interstitial space