Term
| Defintion of Orofacial Clefts |
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Definition
| Faults in integrity of orofacial complex due to failure of developing facial processes to properly fuse |
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Term
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Definition
| Defective fusion of median nasal process w/ maxillary process |
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Term
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Definition
| Defective fusion of palatal shelves w/ eachother |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Etiology of CL+/ CP and CPO is unclear but is... |
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Definition
| Multiple and multifactorial |
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Term
| Syndromic (350 identified so far - up to 30% of CL +/ CP and 50% of CPO have other assoc anomalies) examples assoc with CL/CP |
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Definition
Single gene syndromes w/ specific mendelian patterns
Isolated chromosomal anomalies
Idiopathic |
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Term
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Definition
| specific gene-associated and/or environmental |
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Term
| CL and CP most commonly occur in... |
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Definition
| Native Americans (then Caucasians, then Asians) |
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Term
| CPO occurs very little in... |
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Definition
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Term
| CL +/ CP favors which gender? |
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Definition
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Term
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Definition
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Term
| ____% of CL is unilateral, ____% is bilateral |
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Definition
80;20
(Of unilateral cases, 70% on left side, 70% assoc w/ CP) |
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Term
___% of bilateral CL is assoc w/ CP
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Definition
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Term
| Examples of incomplete forms of CL & CP |
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Definition
Bifid uvula
Submucous cleft of soft palate |
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Term
| Side effects of orofacial clefts: |
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Definition
Malocclusion due to collapse of max. arch
missing or supernumerary teeth |
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Term
| Median anterior maxillary alveolar cleft |
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Definition
| Cleft in the anterior maxillary alveolus due to rare failure of fusion of median nasal processes |
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Term
| Median mandibular alveolar cleft |
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Definition
| Cleft in midline of anterior mand. alveolus due to rare failure of fusion of mand. processes |
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Term
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Definition
| Can be surgically performed during first few months of life |
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Term
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Definition
| Can be surgically performed later when growth slows down |
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Term
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Definition
| 3-5% incidence of clefting in sibling or offspring of affected patient if no other first-degree relatives are affected; 10-20% if they are affected |
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Term
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Definition
| Risk may be higher depending upon specific inheritance pattern |
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