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Developmental biology
Developmental biology lecture 10
10
Biology
Undergraduate 3
07/17/2012

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Term
bicoid
Definition
mRNA that moves on the dysein motor protein
trans located to anterior of egg
-translated after fertilization
-up regulates hunchback and represses caudel
-important for segmentation
Term
oscar+Nanos
Definition
binds to kinesin and moves posterior where it joins wth nanos
-translated after fertilization
-represses hunchback, up regulates caudal
mutants lack an abdomen
Term
Gurken
Definition
binding protein,oocyte nucleus migrates with gurken inducing follicles to be dorsal
Term
first morphogeneic event
Definition
invagination of 16 most vegetal cells forning ventral furrow
Term
Torso
Definition
deposited in oocyte
translated after fertilization
-only activated by toros-like protein in follicle cells at the poles
Term
groucho
Definition
inhibits tailess and huckebein gene
Term
GAP GENES
Definition
interact with each other to set 7 segementation domains
-initiated by biocoid and caudal protein
-first zygotic genes to be expressed along A-P axis
bicoid activates expression of hunchback
-hunchback turns on Giant and knirps
-knuppel appears at the lowest level of hunchback
-posterior end: caudal activates caudel and giant
cont....toros initiates expression of tailless and huckebein
Term
Segment polarity genes
Definition
14 segments controlling the head, abdomen and thoraic regions
-14 segments subdivided into 14 parasegments
(each parasegment are independent)
-reinforces 14 established parasegment genes (cell-cell contact)
-interactions take place between cells- cellular bastoderm
Term
pair-rule genes
Definition
activation of pair rule genes by gap genes defines the 14 parasegmented region
expressed during cylce 13
Term
Hox Genes
Definition
genes on choromosome 3(2 regions) specify body parts
antennapedia and bithorax region(muations of A=legs rather than antenna, BT mutations= fly with 3 wings
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