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Development Lecture 2
Flash Cards from Medical school human development course
28
Medical
Graduate
10/08/2010

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Cards

Term
Occult Dysraphic States AKA myelodysplasia
Definition
Error of secondary neurulation. Group of malformations due to abnormal development of caudal level of spinal cord. Covered with skin (occult=hidden). delay in sphincter control, foot anomalies
Term
(mero)anencephaly
Definition
Absence of calvaria. Rudimentary mass of forebrain and midbrain. increased alpha fetoprotein levels can diagnose this
Term
Meningoencephalocele
Definition
bifid cranium with herniation of brain and meningeal coverings
Term
Cranial meningocele
Definition
small skull defect with with herniated meningial sac filled with CSF. No brain herniation
Term
Cranium bifidum
Definition
opening btwn skull bones. usually asymptomatic
Term
Myeloschisis (spina bifida aperta)
Definition
neural plate open dorsally, no neural tube formation in this area. no function below lesion. Most severe spina bifida
Term
Meningomyelocele
Definition
cystic swelling covered by skin or membrane. herniation of spinal cord and meninges. No function below lesion. Most common of spina bifida cystica (90%)
Term
Meningocele
Definition
vertebral defect. herniated meningial sac filled with CSF. Least common of SB cystica (10%)
Term
Spina bifida occulta
Definition
in 10% of population. Vertebral defect limited to 1-2 vertebrae. usually asymptomatic. may be assoc with skin dimple, fatty cyst, hair tuft, or diastematomyelia (bone spur in spinal canal that can tether spinal cord and keep it from ascending)
Term
Holoprosencephaly
Definition
Failure of bilateralization of the forebrain
Term
During what weeks does primary neurulation occur
Definition
Weeks 3-4
Term
During what weeks does secondary neurulation occur
Definition
weeks 4-8
Term
Five regions of the developing brain
Definition
(from cranial to caudal)- Telencephalon, Diencephalon, Mesencephalon, Metencephalon, myelencephalon
Term
What brain region forms the cerebellum
Definition
metencephalon
Term
What brain region forms the cerebral hemispheres
Definition
the telencephalon
Term
what brain region forms the midbrain
Definition
mesencephalon
Term
what brain region forms the pons
Definition
metencephalon
Term
what brain region forms the medulla
Definition
myelencephalon
Term
Megalencephaly
Definition
over-proliferation of neurons, causes enlarged head
Term
Microencephaly
Definition
under-proliferation of neurons. small head
Term
Lissencephaly
Definition
smooth cortex.
Term
communicating hydrocephalus
Definition
CSF can get into subarachnoid space but can't get to the subarachnoid granulations
Term
Non-communicating hydrocephalus
Definition
CSF can't get into subarachnoid space. Block is usually at cerebral aqueduct
Term
Arnold-Chiari malformation
Definition
caudal displacement and herniation through the foramen magnum of ventrally located cerebellar structures. The direction of some of the cervical roots may be rotated 180 degrees
Term
Precursors for primary sensory neurons
Definition
mostly neural crest cells. some in head by ectodermal placodes
Term
Precursor for somatic motor neurons
Definition
neuroepithelium
Term
Precursor for preganglionic autonomic neurons
Definition
neuroepithelium
Term
precursor for postganglionic autonomic neurons
Definition
neural crest cells
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