Term
| What is the most likely metal in jewelry to cause allergic contact dermatitis? |
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Definition
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Term
| Vitamin used in treatment of measles? |
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Definition
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Term
| What is the presentation of acute graft versus host disease? |
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Definition
| A pt 2 weeks post BMT presents with a pruritic maculopapular rash found predominantly on his face, hands, and feet. He also has bloody diarrhea and abnormal liver function tests. |
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Term
| What is the pathopysiology of GVHD? |
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Definition
| recognition of host major and minor HLA antigens by donor T-cells and consequent cell mediated immune response. |
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Term
| What is Staphylococcal scalded skin syndrome cause by? |
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Definition
| Exfoliative toxin-producing strains of S. aureus. It starts with a prodrome of fever, irritability, and skin tenderness which is followed by erythema and superficial flaccid blisters with + Nikolsky sign. Scaling and desquamation follow before resolution. |
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Term
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Definition
| a form of primary herpes simplex virus infection that is a/w atopic dermatitis. It is usually superimposed on healing eczema after an exposure to HSV. Numerous umbilicated vesicles over the area of healing are typical. It is frequently a/w fever and adenopathy. In infants, this may be life threatening, and acyclovir should be initiated as soon as possible. |
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Term
| Erythema multiforme major |
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Definition
| (=SJS) This is an immune complex mediated hypersensitivity. The most commonly involved drugs are sulfonamindes, NSAIDs, and phenytoin. There is typically a sudden onset mucocutaneous lesions over 2 sites (usually conjunctival and oral) and the lesions have a characteristic target appearance, and are considered pathomneumonic. There will also be systemic signs of toxicity. |
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Term
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Definition
| Seborrheic dermatitis. This is a papular, scaly rash that tends to affect the eyebrows, nasolabial folds, and scalp. Treatment consists of moisturizers, antifungals, and topical steroids. |
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Term
| Exaggerated sunburn in a patient who has just started acne medication: |
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Definition
| Tetracycline induced phototoxic drug eruption. Produced by oxygen free radicles produced by the interaction of drug metabolites with ultraviolet radiation. These radicals directly damage the skin. |
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Term
| What other autoimmune conditions is vitiligo a/w? |
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Definition
pernicious anemia
autoimmune thyroid disease
IDDM
primary adrenal insufficiency
hypopituitarism
alopecia areata |
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Term
| Presentation of contact dermatitis: |
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Definition
| erythema, edema, pruritus, tiny vesicles, and weepy or crusted lesions 24-48 hours after contact with an allergen. It is due to cell mediated (type 4) hypersensitivity. |
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Term
| most frequent cause of ringworm? |
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Definition
| Trichophyton rubrum (tinea corporis) |
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Term
| Malignant acothis nigricans: |
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Definition
| a/w underlying neoplasms, esp of the GI and GU tract. The sudden appearance of acanthotic skin changes in middle-age or elderly patients is suggestive of an underlying malignancy. |
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Term
| How do you treat frostbite? |
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Definition
| Rapid rewarming with warm water. This results in less tissue damage than treatment with slow rewarming. The extremity should be immersed in warm water which is continuously circulated. |
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Term
| Why do ACE inhibitors lead to angioedema? |
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Definition
| Because one of the normal functions of ACE is to degrade bradykinin. Bradykinin is a pro-inflammatory actor, promoting edema, inflammation, and pain. |
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Term
| Angioedema in someone who is not on an ACEi: |
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Definition
-rapid onset non-inflammatory edema of the face, acral extremities, genitals, trachea, and abd orgas.
-Due to a deficiency of C1 esterase inhibitor, which results in elevated leves of edema producing factors C2b and bradykinin. |
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Term
| When do you give oral isotretinoin to patients with acne? |
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Definition
1. Moderate-to-severe acne that is predominantly nodulocystic.
2. Patients who have developed scars |
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Term
| Dermatitis herpetiformis: |
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Definition
| pruritic papules and vesicles over extensor surfaces and by the presence of anti0endomysial antibodies in the serum. Patients also suffer from celiac sprue or gluten sensitive enteropathy. There is an increased risk for GI lymphomas, which can be reduced with a gluten-free diet. |
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Term
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Definition
| toxin-mediated acute febrile illness related to endotoxin-producing S. aureus. Pts present with feveres, hypotension, and a generalized erythema that later desquamates. |
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Term
| What is the causative agent of tinea versicolor? |
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Definition
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Term
| Where is the lesion on a biopsy of bullous pemphigoid? |
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Definition
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Term
| Where is the lesion on a biopsy of pemphigus vulgaris? |
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Definition
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Term
| Well-defined lesion with silvery scale located on the extensor surfaces: |
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Definition
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