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Depression
Overview
39
Aerospace Engineering
1st Grade
04/11/2013

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Cards

Term
improved mood, modulation of anxiety, sleep regulation, appetite regulation, body temp regulation
Definition
Serotonin (5-HT2)
Term
improved mood; fight or flight; mental organization; rewards; cardiovascular
Definition
Norepinephrine (NE)
Term
improved mood; psychosis; attention/cognition; reward/reinforcement of pleasure; motor function
Definition
Dopamine (DO)
Term
Urinary retention; dry mouth, constipation; tachycardia; learning; muscle action
Definition
Acetylcholine (ACH)- antagonism
Term
sedation; weight gain
Definition
Histamine (H1)- antagonism
Term
antidepressant groups usedi n treating depression and anxiety
Definition
selective serotonin reuptake inhibitors (SSRIs); serotonin norepinephrine reuptake inhibitions (SNRIs); monamine oxidase inhibitors (MOIs); atypical antidepressants
Term
not as selective as you think they are!
Definition
selective serotonin reuptake inhibitors
Term
Fluoxetine (Prozac); Sertraline (Zoloft); Fluvoxamine (Oluvox); Citalopram (Celexa); Escitalopram (Lexapro); Paroxetine (Paxil)
Definition
SSRIs
Term
has an active and inactive isomer; modulates the anxiety it causes; an SSRI he uses
Definition
Citalopram
Term
has an active and inactive isomer; modulates the anxiety it causes; an SSRI he uses
Definition
Citalopram
Term
Should be discontinued in the U.S. like it is in the U.K (SSRI)
Definition
Paroxetine (paxil)
Term
anxiety, agitation, akathisia, panic, insomnia, sexual dysfunction, hyponatremia, decrease in platelet aggregation; bleeding risk
Definition
SSRIs adverse effects
Term
Amitriptyline, Clomipramine, Desimpramine, Doxepin, Duloxetie, Imipramine, Nortriptyline, Venlafaxine/desvenlafaxine
Definition
SNRIs
Term
shouldn't use... takes care of the depression but doesn't solve their anxiety. terrible withdrawal (SNRI)
Definition
Venlafaxine/desvenlafaxine (Effexor/Pristiq)
Term
brought on the market for neuropathy, has been okayed for depression; expensive; dose is not strong enough (SNRI)
Definition
Duloxetine (Cymbalta)
Term
severe sedation; constipation; weight gain; cardiovascular; orthostatic hypotension; sexual dysfunction; insomnia; sweating; tremors
Definition
SNRI adverse effects
Term
Phenelzine (Nardil); Tranylcyromine (parnate); Selegiline (Eldepryl)
Definition
Monamine Oxidase Inhibitors (MAOIs)
Term
orthostatic hypertension; drowsins; constipation; tremors; hypertensive crisis; anxiety
Definition
MAOIs Adverse Effects
Term
have to be very careful with diet; a lot of interactions with these drugs
Definition
MAOIs
Term
inhibits reuptake of serotonin and norepinephrine; 5HT-2 and alpha1 receptor antagonists --- not used anymore because of liver failure
Definition
Nefazodone (Serzone)
Term
somnolence, dizziness, constipation, orthostatic hypotension, liver failure (rare, 1 in 250,000-300,000)
Definition
Nefazodone (Serzone)
Term
inhibits reuptake of serotonin, histamine, alpha1-adrenergic receptor antagonists
Definition
Trazodone (Desyrel)
Term
blurred vision, dizziness, dry mouth, nasal congestion, priaprism; used mainly for side effect (drowsiness)
Definition
Trazodone (Desyrel)
Term
blocks reuptake of norepinephrine and dopamine
Definition
Buproprion (Wellbutrin)
Term
used for depression, smoking deterrent, ADHD; Adverse events: headache, dry mouth, weight loss, insomnia, agitation/anxiety
Definition
Bupropion (Wellbutrin)
Term
presynaptic alpha2 antagonist effects stimulates norepinephrine and serotonin release; potent antagonist of 5HT2, 5HT3 and histamine receptors
Definition
mirtazapine (remeron)
Term
somnolence, weight gain, increased appetite, constipation, xerostomia
Definition
mirtazapine (remeron) adverse effects
Term
selective serotonin reuptake inhibitor and partial agonist of 5HT1A receptors (exact MOA is not entirely known)
Definition
Vilazodone (VIIBRYD)
Term
GI-- diarrhea, nausea; neurological- dizziness, insomnia; cardiovascular- palpitations, ventricular premature beats
Definition
Vilazodone adverse effects
Term
decreased anxiety; improved sleep; improved appetite
Definition
first week (symptom remission)
Term
increased activities; sex drive, self-care, memory; thinking and movement normalizing; sleeping and eating patterns normalizing
Definition
1-3 weeks
Term
relief of depressed mood; less hopelessness and helplessness; thoughts of suicide subside
Definition
2-4 weeks
Term
no symptoms or significant reduction in depressive symptoms for at least 2 weeks
Definition
Response
Term
a period of 2 weeks and <2 months with no or few depressive symptoms
Definition
remission
Term
absence of significant symptoms of depression (e.g. no more than 1-2 symptoms for 2 months)
Definition
recovery
Term
relapse a DSM episode of depression during the period of remission
Definition
relapse
Term
emergence of symptoms of depression during the period of recovery (a new episode)
Definition
recurrence
Term
continuation of treatment
Definition
recommended for at least 6-12 months for all responders to acute treatment
Term
lack of patient education with medication; choice of medication prescribed; understanding possible side effect issues: activation, insomnia, akathisia
Definition
possible mechanism for suicide
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