Term
| Antidepressants: do what in the body? |
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Definition
| increase the concentration of norepinephrine, serotonin, and/or dopamine in the body. |
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Term
| amitriptyline (Elavil) TCA |
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Definition
- oldest most widely used TCA
- 1st gen. antidepressant
- highest risk of suicide because; NO antidote for OD or poisoning
- SE: dysrythmias, seizure, headache
- caution: w/ hepatic, renal & cardiac dysfunction
- no concurrent use w/ MAOI, St. Johns wort due to hypertensive crisis and possible death
- Monitor: BP, and cardio
- up to 4wks for results. give @ night due to sedative effect
- **DON'T stop abruptly**
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Term
| clomipramine (Anafranil): TCA |
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Definition
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Term
SSRI: selective seratonin reuptake inhibitor
antianxiety |
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Definition
- 10-14 day for noticeable effects & 4-6 wks for full effect
- inhibits reuptake of serotonin
- NO concurrent use of MAOI or St.Johns Wort
- SE: dizziness, tremors, nervousness, insomnia, N/D, constipation, dry mouth, sexual dysfunction, weight loss/gain,
- HIGH RISK suicide under 18yrs old**
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Term
| fluoxetine (Prozac): SSRI |
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Definition
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Term
| sertraline (Zoloft): SSRI |
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Definition
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Term
|
Definition
used to treat:
- OCD
- GAD
- panic disorder
- social phobia
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Term
|
Definition
- **potential for hypertensive crisis w/ ingestion of foods high in tyramine**
- must have 2wk washout before changing therapy to SSRI or from SSRI
- changing from fluoxitine needs 5wk washout
- educate pt on not using foods containing tyramine containing foods (aged cheese, wine etc)
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Term
| seleiline (Elderpry): MAOI |
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Definition
- used to treat early stage Parkinson's disease
- depression
- senile dementia
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Term
|
Definition
- Nardil
- Parnate
- Marplan
- Elderpry
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Term
bupropion (Wellbutrin): antidepressant, aminoketones |
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Definition
- treats depression, smoking cessation
- inhibts reuptake of dopamine, norepi, serotonin
- SE: headache, agitation, N/V, rash, impotence
- 2-4wk to see effects
**Precaution if seizure or head injury as it lowers threshold |
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Term
| lithium carbonate: antimanic |
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Definition
|
Toxicity level >1.5mEq/L
Must have adequate Na+ in diet to avoid lithium toxicity
2,500-3,000mL fluid daily |
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Term
valproic acid (Depakote): anticonvulsant |
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Definition
- ↑GABA in the brain
- reduce manic episodes, adjunct to schizophrenia
- SE: sedation, drowsiness, N/V/D/constipation, dizziness, hepatic failure
- must wean off slowly to prevent seizures; can cause physical dependency
- **therapeutic range is 50-100**
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