-Vestibule - opening of Bartholin's glands, Vagina + Urethra

-Labia Majora - "Outer Lips" like skin

-Labia minora - "Inner Lips" thin eratin outside, non near vagina, no hair few glands

-Vagina lined by Strat. Sqam.

-Bartholin's Gland ducts lined by transitional, then lead to squamous at opening

-Outer Exocervix : Squamous

-Inner Ednocervix : Mucinous columnar

Where these meet is a VERY important Transitional Zone (squamo-columnar junction)

-Squamo metaplasia can occur (change to mucinous as one ages)

-CANCER CAN DEVELOP HERE!

-Paried Mullerian dicts fuse to form Tubes + Uterus

Consists of:

-Exo/endo cervix and T zones

-Cervical Stroma (fibro CT with elastic and smooth muscle)

-Endometrium inner lining

-Myometrium stretching muscle layer

-Hypo. releases GnRH

-Ant. Pit. releases LH and FSH

-Stimulates ovary at certian times which leads to release of estrogen and progesterone

-Stimulates Ant. Pit. to release FSH and LH

 -Releases hormes in a pulatile fashion

-LH is MORE sensitive to the fluctuations

-Secreted from Ant. Pit.

-Causes negative feeback on GnRH

-Stimulates follicle development

-Stimulates ovary to secrete estrogen and prgesterone

-Midcycle surge leads to Ovulation and formation of the Corpus Leuteum (which produces estro. and prog.)

-LOW levels of estro. exert neg. feedback on FSH and LH

-HIGH rising levels eventualy lead to pos. feedback leading to the LH surge

Preganancy: b-HCG replaces LH to maintain the CL

No Pregnancy: CL is not maintained because Estro/Prog exert negative feedback on LH

-CL regresses and E/P levels drop

-Negative feedback removed and LH and FSH can begin a new cycle

-Proliferative endo. is seen in 1st half of ovarian cycle only: ESTROGEN effect only! (Blue donuts)

Changes to....

-Secretory endo. seen after ovulation: ESTRO and PROG both effect it (piano keys)

-Ideal menstrual cycle is 28 days: 

Day 1 = Day 1 of Menses

Day 14 = Ovulation

-2 layer of the endo.

-Functioalis is what is SHED

-Basilis is the actual tissue left behind

Resposible for:

-Gametogenisis

-Sex hormone production (estro/prog)

Finction controlled by FSH and LH

-Surface epithelium

-Germinal Inclusion Cysts

-Nonspecialized Stroma: plump spindle cells

-Specialized  Stroma: Theca + Granulosa cells

-Germ cells

-Hilus Cells

-Rete Ovarii

-Small cysts lined by cuboidal epithelium

-Thought to be pinched off from indentations of surface epithelium.

-Structure formed from primary sex cords

-Female counterpart to the rete testis

-Primordial follicles turn into primary oocytes (single layer)

-Follicle stimulated to develop by FSH -> becomes a Preantral Follicle

-Continued Development causes formation of Fluid Filled Antrum -> Antral Follicle

AF has an inner granulosa layer and avascular Theca Interna

-Also known as Primordial Germ Cell

-Undergo mitosis as fetus to become Primary Oocytes

-Primordial Follicles are a Primary Oocyte surrounded by single layer of follicular cells

-400,000 at birth

-Meiosis for the PO's starts in fetus and is frozen till follicle maturation

-Meiosis 1 completes to form Secondary Oocyte

(M2 won't occur unless fertilized)

-Developing follicle is stimulated by FSH

-> leads to formation of the Antrum, then-> inner granulosa later -> Theca interna -> Outer Theca Interna ->Theca Externa Spindle Cells

-Produces Androstenedione (also predominated in menopause)

-This is converted to Estradiol by Gran. cells

-Estradiol feeds back to CNS, inhibiting FSH and leading to LH surge

-This causes Ovulation

-Formation of Corpus Luteum

-CL produces Estro. and Prog.

-No Prego: regreses into whitish Corpus Albicans

-Yes Prego: Continues as Corpus Luteum

 -CL is maintained by LH, BUT, Prog. produced by the CL inhibits LH release

-In order for CL to be maintained, HCG must be released during pregnancy

-Lined by Intercalated Ciliated and Nonciliated Columnar Ep.

-Muscular Wall with Inner Circular and Outer Long. Layers

-Chlamydia can cause scarring and lead to tubal preganacy

-Plan B "morning after pill" prevents implantation of follicle

-Modified Apocrine Sweat Glands

-Multiple Lobules Radiate from nipple

-Lobes embedded in adipose

-Lobes drain via Lactiferous Duct onto nipple

-Estrogen: Ductal growth

-Progesterone: Alveolar development

-E+P: increased # of secreting acini

-Prolactin: Milk production/secretion

-Oxytocin: Myoepithelial cell contraction -> secretion

-Ducts lined by inner Cub/Colum and outer myoepithelial layer

-Lobule = Group of terminal acini/ducts surrounded by CT stroma

-Lobule + Draining Duct = Terminal Duct Lobular Unit

-TDLU is where CANCER DEVELOPS

1. Lumen

2. Endometrium:

A. Stratum Functionalis, divided into:

-Stratum Compactum

-Stratum Spongiosum

B. Stratum Basalis

3. Myometrium