Term
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Definition
1. it is volatile, a social issue, there is stigma associated with it, job loss, health care loss
2. record keeping and public health ie. CDC in 1981 (physician reports)
3. understanding disease and prevention |
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Term
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Definition
1983
-a diagnosable disease indicative of cellular immunodeficiency
-cause unknown except for presence of HTLV-III/LAV |
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Term
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Definition
1987
-positive HIV test
-at least one of 23 diseases associated with AIDS |
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Term
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Definition
1993
-positive HIV test
-T-cell count of less than 200 per microliter
-at least one of 26 diseases associated with AIDS |
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Term
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Definition
2000
-positive HIV antibody test
-T-cell count of less than 200 per microliter
-difference for children and adults
-definitive stages from HIV infection to AIDS |
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Term
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Definition
-initial infection (Acute Primary Infection)
-HIV rapidly multiplying in naive CD4 cells and macrophages
-after about 2 weeks flu-like symptoms occur from immune system fighting off infection
-within 2 months, body develops antibodies against HIV |
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Term
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Definition
-asymptomatic incubation period (2-15 years)
-"clinical latency" - some HIV are lysogenic proviruses but some are still multiplying
-about 5% of patients are non-progressors are never leave stage 2 |
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Term
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Definition
transitional phase between 2 and 5
ARC (AIDS Related Complex) symptoms:
-lymphadenopathy (swollen lymph nodes) in neck, armpit, and groin
-weight loss (up to 10%)
-constant low-grade fever (100)
-diarrhea
-overwhelming fatigue
-night sweats
-Thrush (candida, mouth cottage cheese) |
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Term
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Definition
-overt symptoms of AIDS
-loss of immune function |
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Term
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Definition
-initial infection, # of HIV increases rapidly
-immune system response: CD4 cells are sent to eliminate HIV. effective, but viral load does not go completely to zero
B-cells respond and produce anti-HIV antibodies (help control infection) |
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Term
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Definition
-immune system initially controls HIV and keeps viral load low (cellular warfare on a massive scale)
-B-cells pump out antibodies
-CD4 cells respond
-100 billion new HIV every day
-lose 20 million CD4 cells every day = gradual decline |
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Term
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Definition
-beginning to lose war with HIV
-T-cell count <400/microliter
-viral load start to gradually increase
-ARC begins |
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Term
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Definition
-CD4 count <200/microliter
-war is lost :(
-viral load is uncontrollable
-not making any more antibodies (amount levels off)
-begin disease of HIV and opportunistic infections |
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