Term
| What type of organisms are common with x-linked agammglobulinemia? |
|
Definition
-encapsulated organisms
-haemophilus influenzae
-pneumococci
-streptococci
-staphylococci
-menigiococci |
|
|
Term
| Delayed clinical manifestations associated with X-LA is due to what? |
|
Definition
| IgG from mothers until 6-15 months of age. |
|
|
Term
| For which immunoglobulin deficiencies do you use gamma-globulin for treatment. |
|
Definition
| X-LA, Common Variable Immunodeficiency, Hyper-IgM syndrome |
|
|
Term
| What is the most common age of onset for common variable immunodeficiency? |
|
Definition
|
|
Term
| What clinical manifestations are common for Common Variable Immunodeficiency? |
|
Definition
-Infectious diarrhea
-Malabsorption syndrome
-Bronchiectasis |
|
|
Term
| What is expected in labs for Common Variable Immunodeficiency? |
|
Definition
| Low levels of all immunoglobulins, immature B-cells. |
|
|
Term
| What is the most common immunodeficiency in whites? |
|
Definition
| Selective IgA deficiency. |
|
|
Term
| What is present in 70% of patients with ataxia-telangectasia? |
|
Definition
|
|
Term
| What is the most important feature of cell-mediated immunity or t-cell deficiencies? Which organisms are opportunistic? |
|
Definition
-Extreme susceptibility to opportunistic infections.
-Candida albicans, enteric bacteria, viruses and fungi |
|
|
Term
| What is markedly depleted in severe combined immunodeficiency? |
|
Definition
|
|
Term
| What are the most common clinical manifestations for severe combined immunodeficiency? |
|
Definition
chronic pulmonary infections, moniliasis, failure to thrive (3-6 months of age).
Treatment with bone marrow transplant. |
|
|
Term
| Normal levels of IgG, elevated levels of IgE and IgA and low levels of IgM with severe thrombocytopenia is associated with what? |
|
Definition
|
|
Term
| Cerebellar ataxia and increased incidence of lymphoid malignancies are seen with what? |
|
Definition
| Immunologic deficiency with ataxia-telangectasia |
|
|
Term
| What are people with immunoglobulin deficiency syndromes susceptible to? |
|
Definition
| recurrent pyogenic infections |
|
|
Term
| What accounts for >50% of immunodeficiency syndromes? |
|
Definition
| common variable immunodeficiency |
|
|
Term
| People with immunoglobin deficiencies are more at risk for what? |
|
Definition
| recurrent pyogenic infections: otitis media, sinusitis, and pneumonia |
|
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