Term
| Fatty acid synthesis requires _____ as its precursor and this molecule. |
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Definition
|
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Term
Can acetyl CoA cross the mitochondrial membrane?
What transport system does it use? |
|
Definition
| No, uses tricarboxylate transport system (malate shuttle). |
|
|
Term
Citrate is broken down to what two molecules?
Where?
What enzyme? |
|
Definition
OAA and acetyl CoA
cytosol
ATP citrate lyase |
|
|
Term
When is fatty acid synthesis initiated?
|
|
Definition
| When citrate is exported into cytoplasm. |
|
|
Term
Review the Malate transport pathway.
What is the purpose? |
|
Definition
| Shuttle acetyl CoA to the cytosol and regenerate OAA and acetyl CoA |
|
|
Term
| OAA is reduced to malate by what enzyme? |
|
Definition
| malate dehydrogenase and NADH |
|
|
Term
| Is pyruvate permeable to the inner mitochondrial membrane? |
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Definition
|
|
Term
| Fatty acid biosynthesis combines _____ ____ to form ______. |
|
Definition
| 8 2-C fragments from acetyl CoA to make palimate |
|
|
Term
| What are the two steps in fatty acid synthesis? |
|
Definition
1. Acetyl CoA carboxylase (irreversible, biotin, ATP)
2. Fatty acid synthase |
|
|
Term
Acetyl CoA carboxylase is ______ by ______.
1. citrate -- stimulated
2. epi, glucagon, NE -- inhibited
insulin -- stimulated
3. malonyl Co-A -- stimulate |
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Definition
|
|
Term
| What does palmitoyl CoA do to Acetyl CoA carboxylase? |
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Definition
|
|
Term
| Phosphorylated Acetyl CoA Carboxylase is in the ____ form, done by this hormone. |
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Definition
|
|
Term
| Palimate is activated in this form. |
|
Definition
|
|
Term
T/F Elongation of palmitoyl CoA (activated) can occur is most tissues.
T/F Desaturation " ". |
|
Definition
|
|
Term
| Two places elongation can occur in a cell. |
|
Definition
ER (malonyl CoA, NADPH)
Mitochondria (acetyl CoA, NADH, NADPH) |
|
|
Term
Which elongation process resembles de novo fatty acid synthesis?
Which elongation process is essential the opposite of B oxidation? |
|
Definition
|
|
Term
| Synthesis of TAGs occurs in which two tissues? |
|
Definition
|
|
Term
| What is the clinical importance of adipose lacking glycerol kinase? |
|
Definition
| Can only make f'a's when glucose is available using DHAP (ie, in fed state) |
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