Term
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Definition
| process where a drug or other solute is partitioned between immiscible phases |
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Definition
| The ratio of the solute concentrations in the two immiscible phases at equilibrium. |
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Definition
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| Nonelectrolytes exist as __________ in the aqueous and oil phases. |
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Definition
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Definition
True partition coefficient |
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Term
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Definition
The apparent partition coefficient |
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| a commonly used oil in distribution work is __________ |
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Definition
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Definition
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| The distribution of weak acids between oil and aqueous phases is affected by the ____________ |
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Definition
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in weak acids: the true partition coefficient (KD) is the equilibrium concentration ratio of the _______ _______ molecules in oil and water. |
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Definition
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Term
| True/False: The KD of of weak acids is unaffected by the pH of the aqueous medium. |
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Definition
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Term
| True/False: In weak acids the KD' is affected by the pH of the aqueous phase |
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Definition
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Term
The true partition coefficient for weak bases is the equilibrium concentration ratio of the ______ ___ molecules in the oil and water phase. |
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Definition
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Term
| the _____ of weak bases is unaffected by pH |
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Definition
| KD (true partition coefficient) |
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Term
| The equilibrium concentration for the neutral B molecules in the oil phase and the B and BH- molecules in the aqueous phase is given by ______. |
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Definition
| Apparent Partition Coefficient (KD') |
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Term
| True/False: The apparent partition coefficient KD' is unaffected by the pH. |
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Definition
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Term
extraction of drugs is commonly conducted using _______ ____________ organic solvents and ______ phases in many pharmaceutical activities. |
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Definition
| water immiscible, aqueous |
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Term
| Emulsions can be contaminated by ____,______,and ______. |
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Definition
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Term
| ____________ need to be added to emulsions to protect from contamination. |
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Definition
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Term
| Two preservatives that are used in emulsions |
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Definition
| benzoic acid, sorbic acid |
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Term
| The preservative is usually added to the ______ phase. |
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Definition
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Term
| True/False: only the aqueous neutral molecules of the weak acid have preservative action |
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Definition
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