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Daoud Lecture Two
Overview
27
Accounting
Kindergarten
04/28/2013

Additional Accounting Flashcards

 


 

Cards

Term
has a 60-70% enzyme activity: AA change from Arg to Cys (need dose reduction in warfarin)
Definition
CYP2C9*2
Term
has a 5% enzyme activity: AA change from Ile to Leu (need major dose reduction in warfarin)
Definition
CYP2C9*3
Term
predominantly occur in individual of African descent. Require lower warfarin doses
Definition
CYP2C9*5, *6, *8 and *11
Term
highest in Asian (99%), Caucasian (60%), African Americans (26%)
Definition
VKORC1 Haplotype A
Term
target enzyme for warfarin which affects the pharmacodynamics
Definition
VKORC1
Term
VKORC1-1639 genotypes
Definition
GG, AG, AA
Term
5 non-coding SNPs in linkage disequilibrium form two common haplotypes (A and B)
Definition
VKORC1 haplotypes
Term
genotypes for loci cleared by the FDA as an in vitro diagnostic device
Definition
in CYP2C9
Term
genotypes for one locus cleared by the FDA as an in vitro diagnostic device
Definition
in VKORC1
Term
test NOT commercially available
Definition
CYP4F2
Term
defined as muscle pain or weakness with elevated creatinine kinase levels
Definition
statin induced myopathy
Term
talked about synonymous SNP variants with no change to AA but had effects on Efavirenz, Cyclosporine
Definition
P170 glycoprotein (PGP)
Term
expressed on the cell membrane and acts as a pump that removes drug within the cell
Definition
multidrug resistance pumps (MRPs)
Term
important for statin transport into the hepatocyte
Definition
organic anion transporters (OAT)
Term
encodes for the organic anion transporting polypeptide C (OAT1B1)
Definition
SLCO1B1*5
Term
OAT1B1
Definition
organic anion transporting polypeptide C
Term
transports statins (except Fluvastatin!) to hepatocytes
Definition
OAT1B1
Term
SNP (5521T>C) nucleotide change results in amino acid change
Definition
Val174Ala
Term
SLCO1B1*5
Definition
reduces OAT1B1 transport activity --> increased drug plasma concentrations possibly causing toxicity (myopathy)
Term
highest in Caucasian (16%), Asian (10-16%), African Americans (1-2%)
Definition
SLCO1B1*5
Term
encodes for Kinesin-like Protein 6
Definition
KIF6
Term
associated with an increased risk of CHD (statins are not able to be transported along microtubules)
Definition
KIF6 719 Trp/Arg SNP
Term
highest in African Americans (83%); Asian (39-56%) and Caucasian (36%)
Definition
KIF6 719 Arg
Term
PROVE IT-TIMI 22 study showed that KIF6 719Arg carriers benefit
Definition
high statin doses (Atorvastatin 80 mg/day compared to pravastatin 40 mg/day)
Term
did NOT benefit from high-dose statin therapy
Definition
Trp allele homozygotes
Term
high-dose statins should be avoided in patients with this allele to reduce potential risk for myopathy; lower dose or consider Fluvastatin (high dose)
Definition
SLCO1B1*5
Term
testing is commercially available and costs about $500
Definition
SLCO1B1*5 and KIF6 719Trp/Arg genotypes
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