Term
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Definition
Function: Similar to TNF (fever production & induces liver acute phase proteins).
Pro-inflammatory cytokine
Produced in: Macrophages; Endothelial cells. |
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Term
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Definition
| Fxn: T cell growth factor |
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Term
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Definition
Fxn: Inhibits Th1 cell development. Isotype switching to IgE. Stimulate development of Th2 cells.
Produced in: Th2 cells. |
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Term
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Definition
Fxn: Activate eosinophils to release granules. Isotype switching to IgE.
Produced in: Th2 cells, Mast cells |
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Term
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Definition
Fxn: Inhibit IL-12, decrease class II MHC.
Anti-inflammatory cytokine.
Produced in: Macrophages, T regulatory cells. |
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Term
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Definition
Fxn: Activates NK and T cells to produce IFN-γ. Enhances cytolytic activity of NK and CD8 T cells. Kill intracellular microbes by promoting Th cells.
Produced in: Mononuclear phagocytes, dendritic cells. |
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Term
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Definition
Fxn: Isotype switch to IgE. Increase epithelal mucus productions.
Produced in: Th2 cells, NK cells, Mast cells. |
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Term
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Definition
Fxn: Increase chemokine and cytokine production. Activate neutrophils, promote inflammation.
Produced in: Th-17 cells |
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Term
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Definition
Fxn: Inhibit viral replication. Increase expression of class I MHC and enhance killing by CD8 T cells.
Produced in: α- virally infected cells, mononuclear phagocytes; β- Fibroblasts |
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Term
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Definition
Fxn: Induces Th1 and B cell isotype switch to opsonizing and complement (IgG). Inhibit Th2 cell production. Main macrophage activator (increase MHC I and II). Combat viral and intracellular infection. Inflammation. Augments TNF production.
Produced in: Signature cytokine of Th1 |
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Term
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Definition
Low concentration: stimulate recruitment of neutrophils & monocytes, stimulate adhesion molecules and chemokine secretion by endothelial cells.
Moderate concentration: Systemic effects (fever).
High concentration: intravascular thrombosis & shock (septic shock, inhibit vascular contraction, decrease in BP).
Produced in: Macrophages, T cells (TNF-α), Mast cells (TNF-β) |
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Term
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Definition
Fxn: Activation of effector cells. Inhibit T cell proliferation.
Produced in: T cells, Macrophages |
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Term
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Definition
Fxn: Promotes cell mediated immunity. Induce proliferation of plasma cells. Stimulate IL-17.
Produced in: Macrophages, endothelial cells, T cells |
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