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Cytokines
Immuno
11
Medical
Graduate
04/13/2013

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Term
IL-1
Definition
secreted by macrophages
fever, acute inflammation
Term
IL-6
Definition
secreted by macrophages and Th2
fever
Term
IL-8
Definition
secreted by macrophages
chemotactic factor for neutrophils
Term
IL-12
Definition
secreted by macrophages and B cells
induce differentiation of T cells to Th1 cells
Activates NK cells
Term
TNF-a
Definition
secreted by macrophages
septic shock
Term
IL-2
Definition
secreted by all T cells
stimulates T cells
Term
IL-3
Definition
secreted by all T cells
stimulates bone marrow
Term
Interferon-gamma
Definition
secreted from Th1 cells
activates macrophages and Th1 cells; suppresses Th2 cells
Term
IL-4
Definition
secreted from Th2 cells
stimulates IgE production
Term
IL-5
Definition
secreted from Th2 cells
stimulates IgA production
Term
IL-10
Definition
secreted from Th2 cells and regulator T cells
inhibits actions of activated T cells and Th1 - similar to TGF-B
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