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Cytokines
Sources and targets
13
Biology
Graduate
02/14/2010

Additional Biology Flashcards

 


 

Cards

Term
TNF
Definition

SOURCE: macrophages and Th1 cells

 

TARGETS/EFFECTS:

 

1. Endothelial cells (increased vascular permeability),

2. Neutrophils (activate microbial activity)

3. Hypothalamus (fever)

4. Liver (acute phase protein synthesis)

5. Muscles and fat (catabolism)

6. Other cells (apoptosis)

Term
IL-1
Definition

SOURCE: macrophages

 

TARGETS/EFFECTS:

 

1. Endothelial cells (activation)

2. Hypothalamus (fever)

3. Liver (synthesis of acute phase reaction proteins)

Term
IL-12
Definition

SOURCE: macrophages and dendritic cells;

 

TARGETS/EFFECTS:

 

1. Naive CD4 T cells (Th1 differentiation)

2. NK cells (increased cytolytic activity)

3. T cells (IFN-g synthesis)

Term
Type I IFN (IFN-a and IFNb)
Definition

SOURCE: IFN-a = macrophage, IFN-b = fibroblasts;

 

TARGETS/EFFECTS:

 

1. All cells (increase MHC class I, induce antiviral state)

2. NK cells (activation)

Term
IL-6
Definition

SOURCE: macrophages, endothelium, T cells

 

TARGETS/EFFECTS:

 

1. Liver (acute-phase proteins)

2. B cells (proliferation)

Term
IL-10
Definition

SOURCE: macrophages, activated Th2 cells

 

TARGETS/EFFECTS:

 

1. Macrophages (inhibit IL-12 production)

2. Dendritic cells (inhibit expression of costimulatory B7 and MHC II)

Term
IL-2
Definition

SOURCE: activated CD4 T cells

 

TARGETS/EFFECTS: Th1 and Th2 cells (proliferation)

Term
TGF-b
Definition

SOURCE: activated Th2 cells

 

TARGETS/EFFECTS: Th1 cells (inhibits proliferation)

Term
MIP-1a
Definition

SOURCE: monocytes

 

TARGETS/EFFECTS:

 

1. Leukocytes (recruitment)

2. CD4 T cells (competes with HIV-1)

3. Naive CD4 T cell (promote Th1 cell immunity)

Term
RANTES
Definition

SOURCE: T cells

 

TARGETS/EFFECTS: T cells (activation during chronic inflammation)

Term
MCP-1 (macrophage chemotactic protein)
Definition

SOURCE: monocytes and macrophages

 

TARGETS/EFFECTS:

 

1. Macrophages (activation)

2. Th2 cells (Th2 cell immunity)

Term
Eotaxin
Definition

SOURCE: Endothelium, monocytes, T cells

 

TARGETS/EFFECTS: eosinophils and basophils (recruitment during allergic reaction)

Term
IL-8
Definition

SOURCE: macrophages

 

TARGETS/EFFECTS:

 

1. Neutrophils (recruitment)

2. CD4+ and CD8+ T cells (mobilization)

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