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Details

CYP Chart 1
Given CY P450's
19
Pharmacology
Graduate
09/13/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
1A2 inducers
Definition
rifampin
carbemazepine
phenobarbital
ritonavir
tobacco
Term
2C9 inducers
Definition
rifampin
phenytoin
carbamazepine
phenobarbital
secobarbital
Term
2C19 inducers
Definition
phenytoin
Term
2D6 inducers
Definition
maybe methadone
Term
2E1 inducers
Definition
Ethanol
Isoniazid
Term
3A family inducers
Definition
rifampin
phenytoin
carbamazepine
phenobarbitol
St John's Wart
Troglitazone
Rifabutin
Antiretrovirals
Term
1A2 inhibitors
Definition
amiodarone
cimetidine
fluoxetine
ketoconazole
fluoroquinalones (ciprofloxacin, enoxacin, norfloxacin)
fluvoxamine
zileuton
Term
2C9 inhibitors
Definition
amiodarone
fluoxetine
fluconazole
voriconazole
maybe omeprazole
isoniazid
zafirlukast
Term
2C19 inhibitors
Definition
amiodarone
cimetadine
fluoxetine
fluconazole
voriconazole
lansoprazole
omeprazole
fluvoxamine
isoniazid
modafinil
ticlopadine
Term
2D6 inhibitors
Definition
amiodarone (strong)
cimetidine (strong)
fluoxetine (weak)
bupropion (weak)
clomipramine
duloxetine (middle)
paroxetine (weak)
haloperidol
quinidine (weak)
ritonavir
Term
2E1 inhibitors
Definition
cimetidine (weak)
disulfiram
Term
3A family inhibitors
Definition
amiodarone cimetidine (strong) fluoxetine (weak) itraconazole (weak) ketoconzole (weak) voriconazole fluconazole (less) antiretrovirals nicardipine clarithromycin (weak) erythromycin (less) troleandomycin nefazadone (weak) fluvoxamine grapefruit juice diltiazem verapamil and conivaptan
Term
which have polymorphisms?
Definition
2C9
2C19
2D6
3A Family
(all but 1A2 and 2E1)
Term
2C9 substrates
Definition

tolbutamide

glipizide

tamoxifen

torsemide

phenytoin

S-warfarin

NSAIDs (diclofenac, ibuprofen, piroxicam, naproxen, celecoxib)

ATI antagonists (not candesartan or valsartan)

fluvastatin

 

Term
2C19 substrates
Definition
omeprazole (all PPI's)
phenytoin (all anti-epileptics)
progesterone
R-warfarin
Term
2D6 substrates
Definition
Beta blockers (S-metoprolol, propafenone, timolol)
codeine
tamoxifen
flecainide
mexilitene
Term
2E1 substrates
Definition
APAP
Term
3A family substrates
Definition

 

Oral contraceptives (Estrogens, Progestines)

HMG CoA Reductase Inhibitors (not pravastatin and rosuvastatin)

Calcium Channel Blockers (amlodipine, felodipine, nifedipine, nisoldipine, nitrendipine, diltiazem, verapamil)

eplerinone 

quinidine

digoxin

sildenafil

tamoxifen

Term
1A2 substrates
Definition
theophylline
acetaminophen
naproxen
mexilitene
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